A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Samwel Mchele Limbu; Li‐Qiao Chen; Mei‐Ling Zhang; Zhen‐Yu Du

doi:10.1111/raq.12511

journal article Oct 21, 2020

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Samwel Mchele Limbu

Li‐Qiao Chen Mei‐Ling Zhang Zhen‐Yu Du

Reviews in Aquaculture Vol. 13 No. 2 pp. 1015-1059 · Wiley

View at Publisher Save 10.1111/raq.12511

Abstract

AbstractThe rearing of fish in intensive systems reduces their immunity leading to eruption of diseases, consequently prompting the use of antibiotics. Antibiotics are currently used in cultured fish globally to treat/prevent diseases. On the one hand, antibiotics used in aquaculture help to improve fish health by killing or inhibiting pathogenic bacteria proliferation. However, on the other hand, they cause multiple side effects. To date, information on systemic effects of antibiotics in cultured fish is scattered and their potential human health risk remains elusive. This review critically analyses and discusses the available information in the literature on the positive and negative effects of antibiotics in cultured fish and their potential human health risk via fish consumption. The review found 44 different antibiotics dominated by oxytetracycline were studied in various fish species worldwide. Antibiotics used in global aquaculture either decrease or increase fish growth and survival rates. They induce oxidative stress, which affect antioxidant and detoxification responses and cause host–microbiota dysbiosis. These changes compromise the fish immunity system, which ultimately lead to cellular damage. The toxicities generated inhibit the fish aerobic glycolysis, suppress lipogenesis and fatty acid β‐oxidation while increase energy demand by initiating gluconeogenesis and anaerobic glycolysis. Consumption of fish treated with antibiotics causes human health risk. Future studies are required on agents to restore dysfunctions induced by antibiotics in cultured fish, while attempts to limit their utilisation in aquaculture production are underway. [Correction added on 21 November 2020, after first online publication: The abstract has been amended to clarify the scope of the review.]

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Details

Published: Oct 21, 2020
Vol/Issue: 13(2)
Pages: 1015-1059
License: View

Authors

S

Samwel Mchele Limbu

Laboratory of Aquaculture Nutrition and Environmental Health (LANEH) School of Life Sciences East China Normal University Shanghai China; Department of Aquatic Sciences and Fisheries Technology University of Dar es Salaam Dar es Salaam Tanzania

L

Li‐Qiao Chen

Laboratory of Aquaculture Nutrition and Environmental Health (LANEH) School of Life Sciences East China Normal University Shanghai China

M

Mei‐Ling Zhang

Laboratory of Aquaculture Nutrition and Environmental Health (LANEH) School of Life Sciences East China Normal University Shanghai China

Z

Zhen‐Yu Du

Laboratory of Aquaculture Nutrition and Environmental Health (LANEH) School of Life Sciences East China Normal University Shanghai China

Cite This Article

Samwel Mchele Limbu, Li‐Qiao Chen, Mei‐Ling Zhang, et al. (2020). A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review. Reviews in Aquaculture, 13(2), 1015-1059. https://doi.org/10.1111/raq.12511

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

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