Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

Amruta Manke; Liying Wang; Yon Rojanasakul

doi:10.1155/2013/942916

journal article Open Access Jan 01, 2013

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

Amruta Manke

Liying Wang

Yon Rojanasakul

BioMed Research International Vol. 2013 pp. 1-15 · Wiley

View at Publisher Save 10.1155/2013/942916

Abstract

The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. The unique physicochemical and electrical properties of engineered nanoparticles (NP) make them highly desirable in a variety of applications. However, these novel properties of NP are fraught with concerns for environmental and occupational exposure. Changes in structural and physicochemical properties of NP can lead to changes in biological activities including ROS generation, one of the most frequently reported NP-associated toxicities. Oxidative stress induced by engineered NP is due to acellular factors such as particle surface, size, composition, and presence of metals, while cellular responses such as mitochondrial respiration, NP-cell interaction, and immune cell activation are responsible for ROS-mediated damage. NP-induced oxidative stress responses are torch bearers for further pathophysiological effects including genotoxicity, inflammation, and fibrosis as demonstrated by activation of associated cell signaling pathways. Since oxidative stress is a key determinant of NP-induced injury, it is necessary to characterize the ROS response resulting from NP. Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP-induced injury can be developed.

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Metrics

1,359

Citations

173

References

Details

Published: Jan 01, 2013
Vol/Issue: 2013
Pages: 1-15
License: View

Authors

A

Amruta Manke

Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA

L

Liying Wang

Physiology and Pathology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA

Y

Yon Rojanasakul

Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA

Funding

National Institutes of Health Award: R01-HL076340

National Science Foundation Award: R01-HL076340

Cite This Article

Amruta Manke, Liying Wang, Yon Rojanasakul (2013). Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity. BioMed Research International, 2013, 1-15. https://doi.org/10.1155/2013/942916

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

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