Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review

Konstantinos Anagnostakos; Christof Meyer

doi:10.1155/2017/4657874

journal article Open Access Jan 01, 2017

Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review

Konstantinos Anagnostakos

Christof Meyer

BioMed Research International Vol. 2017 pp. 1-7 · Wiley

View at Publisher Save 10.1155/2017/4657874

Abstract

Knowledge about the elution from antibiotic-loaded cement spacers is an indispensable premise for guarantee of clinical success. A systematic literature search was performed through PubMed. Search terms were “antibiotic elution” and “antibiotic release” in combination with “spacer,” “hip spacer,” and “knee spacer,” respectively. A total of 11 studies could be identified. Seven studies reported on the release of antibiotics after spacer implantation, three studies at spacer removal, and one study on both time points. Seven studies reported on hip spacers, one study on knee spacers, and three studies on both. In eight studies, custom-made spacers have been implanted and in three prefabricated ones. In the majority of the studies, the cement has been loaded with an antibiotic combination, mostly consisting of aminoglycoside (either gentamicin or tobramycin) and vancomycin. Measured concentrations exceeded the minimal inhibitory concentration of the particular pathogen organisms in each case. However, large discrepancies were observed with regard to the height of the antibiotic concentration depending on the antibiotic combination and the antibiotic ratio used. Current literature data indicate a sufficient elution of antibiotics after spacer implantation and at spacer removal, respectively. Future studies are required to optimize the local antibiotic therapy at the site of spacer implantation.

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Details

Published: Jan 01, 2017
Vol/Issue: 2017
Pages: 1-7
License: View

Authors

K

Konstantinos Anagnostakos

Zentrum für Orthopädie und Unfallchirurgie, Klinikum Saarbrücken, Saarbrücken, Germany

C

Christof Meyer

Zentrum für Orthopädie und Unfallchirurgie, Klinikum Saarbrücken, Saarbrücken, Germany

Cite This Article

Konstantinos Anagnostakos, Christof Meyer (2017). Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review. BioMed Research International, 2017, 1-7. https://doi.org/10.1155/2017/4657874

Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review

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