Clinical Characteristics of Pregnancy-Associated Central Serous Chorioretinopathy in the Chinese Population

Jia Yu; Lei Li; Chunhui Jiang; Qing Chang; Gezhi Xu

doi:10.1155/2021/5580075

journal article Open Access Dec 16, 2021

Clinical Characteristics of Pregnancy-Associated Central Serous Chorioretinopathy in the Chinese Population

Jia Yu

Journal of Ophthalmology Vol. 2021 pp. 1-7 · Wiley

View at Publisher Save 10.1155/2021/5580075

Abstract

Purpose. To investigate the clinical characteristics of pregnancy-associated central serous chorioretinopathy (CSC) in the Chinese population. Methods. The medical records of patients diagnosed with pregnancy-associated CSC from February 2012 to October 2019 were retrospectively reviewed. Best-corrected visual acuity (BCVA), symptom duration, pregnancy-related medical information, and optical coherence tomography (OCT) images were collected. Results. Nine patients (11 eyes) were included. Five women were in their first pregnancy and four were in their second pregnancy, two of whom experienced CSC in their first pregnancy as well. The mean age was 35.00 ± 3.97 years. The mean symptom duration at the initial visit was 19.73 ± 13.65 days. The mean gestational age at the time of development of CSC was 27.11 ± 2.09 weeks. The mean BCVA (logarithm of the minimum angle of resolution (logMAR)) at the initial visit was 0.36 ± 0.18 (Snellen 20/45, range 20/100–20/25). All eyes showed subretinal hyperreflective fibrin on OCT images at the initial visit. Four patients (4 eyes) were lost to follow-up before fluid resolution. The mean BCVA at the final visit was logMAR 0.10 ± 0.15 (Snellen 20/25, range 20/50–20/20)). One eye in the oldest patient had persistent subretinal fluid at 26 months postpartum. The subretinal fluid resolved completely after half-dose photodynamic therapy (PDT); however, the ellipsoid zone at the fovea remained discontinuous at 30 months after half-dose PDT. The remaining six eyes all showed spontaneous resolution of subretinal fluid around delivery and regained intact ellipsoid zone. Conclusions. Pregnancy-associated CSC in Chinese developed mostly in the third trimester and usually recovered spontaneously around delivery with good final visual acuity. However, patients might require long-term follow-up until complete resolution of subretinal fluid and to detect recurrences. Half-dose PDT can be administered early if there is little reduction in the amount of subretinal fluid after delivery.

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Metrics

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Citations

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References

Details

Published: Dec 16, 2021
Vol/Issue: 2021
Pages: 1-7
License: View

Authors

J

Jia Yu

Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai 200031, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China

L

Lei Li

Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai 200031, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China

C

Chunhui Jiang

Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai 200031, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China

Q

Qing Chang

Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai 200031, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China

G

Gezhi Xu

Department of Ophthalmology, Eye & Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia (Fudan University), Shanghai 200031, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China

Funding

National Natural Science Foundation of China Award: 81870670

Science and Technology Commission of Shanghai Municipality Award: 81870670

Shanghai Clinical Three-Year Action Plan-Major Clinical Research Project Award: 81870670

Cite This Article

Jia Yu, Lei Li, Chunhui Jiang, et al. (2021). Clinical Characteristics of Pregnancy-Associated Central Serous Chorioretinopathy in the Chinese Population. Journal of Ophthalmology, 2021, 1-7. https://doi.org/10.1155/2021/5580075

Clinical Characteristics of Pregnancy-Associated Central Serous Chorioretinopathy in the Chinese Population

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