Toward the future of psychiatric diagnosis: the seven pillars of RDoC

Bruce N Cuthbert; Thomas R Insel

doi:10.1186/1741-7015-11-126

journal article May 14, 2013

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

Bruce N Cuthbert Thomas R Insel

BMC Medicine Vol. 11 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/1741-7015-11-126

Topics

No keywords indexed for this article. Browse by subject →

References

35

[1]

Wing L, Gould J, Gillberg C: Autism spectrum disorders in the DSM-V: better or worse than the DSM-IV?. Res Dev Disabil. 2011, 32: 768-773. 10.1016/j.ridd.2010.11.003. 10.1016/j.ridd.2010.11.003

[2]

Friedman RA: Grief, depression, and the DSM-5. N Engl J Med. 2012, 366: 1855-1857. 10.1056/NEJMp1201794. 10.1056/nejmp1201794

[3]

Skodol AE: Personality disorders in DSM-5. Annual Rev of Clinical Psychology. 2012, 8: 317-344. 10.1146/annurev-clinpsy-032511-143131. 10.1146/annurev-clinpsy-032511-143131

[4]

Clarkin JF, Huprich SK: Do DSM-5 personality disorder proposals meet criteria for clinical utility?. J Pers Disorders. 2011, 25: 192-205. 10.1521/pedi.2011.25.2.192. 10.1521/pedi.2011.25.2.192

[5]

Phillips J, Frances A, Cerullo MA, Chardavoyne J, Decker HS, First MB, Ghaemi N, Greenberg G, Hinderliter AC, Kinghorn WA, LoBello SG, Martin EB, Mishara AL, Paris J, Pierre JM, Pies RW, Pincus HA, Porter D, Pouncey C, Schwartz MA, Szasz T, Wakefield JC, Waterman GS, Whooley O, Zachar P: The six most essential questions in psychiatric diagnosis: a pluralogue part 1: conceptual and definitional issues in psychiatric diagnosis. Philos Ethics Humanit Med. 2012, 7: 3-10.1186/1747-5341-7-3. 10.1186/1747-5341-7-3

[6]

Phillips J, Frances A, Cerullo MA, Chardavoyne J, Decker H, First MD, Ghaemi N, Greenberg G, Hinderliter AC, Kinghorn WA, LoBello SG, Martin EB, Mishara AL, Paris J, Pierre JM, Pies RW, Pincus HA, Porter D, Pouncey C, Schwartz MA, Szasz T, Wakefield JC, Waterman GS, Whooley O, Zachar P: The six most essential questions in psychiatric diagnosis: a pluralogue part 3: issues of utility and alternative approaches in psychiatric diagnosis. Philos Ethics Humanit Med. 2012, 7: 9-10.1186/1747-5341-7-9. 10.1186/1747-5341-7-9

[7]

Varga S: Defining mental disorder: exploring the ‘natural function’ approach. Philos Ethics Humanit Med. 2011, 6: 1-10.1186/1747-5341-6-1. 10.1186/1747-5341-6-1

[8]

Nesse RM, Stein DJ: Towards a genuinely medical model for psychiatry. BMC Med. 2012, 10: 5-10.1186/1741-7015-10-5. 10.1186/1741-7015-10-5

[9]

Dictionary.com. [ http://www.dictionary.com ]

[10]

Sensky T, Turkington D, Kingdon D, Scott JL, Scott J, Siddle R, O’Carroll M, Barnes RE: A randomized controlled trial of cognitive-behavioral therapy for persistent symptoms in schizophrenia resistant to medication. Arch Gen Psychiatry. 2000, 57: 165-172. 10.1001/archpsyc.57.2.165. 10.1001/archpsyc.57.2.165

[11]

National Heart, Lung, and Blood Institute: NHLBI Fact Book, Fiscal Year. 2011, Bethesda, MD: NHLBI, [ http://www.nhlbi.nih.gov/about/factpdf.htm ]

[12]

Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, Reaman GH, Carroll WL: Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children’s oncology group. J Clin Oncol. 2005, 2012 (30): 1663-1669.

[13]

Kessler RC, Demler RG, Olfson FM, Pincus HA, Walters EE, Wang P, Wells KB, Zaslavsky AM: Prevalence and treatment of mental disorders, 1990 to 2003. N Engl J Med. 2005, 352: 2515-2523. 10.1056/NEJMsa043266. 10.1056/nejmsa043266

[14]

Hyman SH: The diagnosis of mental disorders: the problem of reification. Ann Rev Clin Psychol. 2010, 6: 155-179. 10.1146/annurev.clinpsy.3.022806.091532. 10.1146/annurev.clinpsy.3.022806.091532

[15]

Insel T, Cuthbert B, Garvey M, Heinssen R, Kozak M, Pine DS, Quinn K, Sanislow C, Steinberg J, Wang P: Research Domain Criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiat. 2010, 167: 748-751. 10.1176/appi.ajp.2010.09091379. 10.1176/appi.ajp.2010.09091379

[16]

Clark LA, Watson D, Reynolds S: Diagnosis and classification of psychopathology: challenges to the current system and future directions. Ann Rev Psychol. 1995, 46: 121-153. 10.1146/annurev.ps.46.020195.001005. 10.1146/annurev.ps.46.020195.001005

[17]

Van Praag HM: Nosologomania: a disorder of psychiatry. World J Biol Psychiatry. 2000, 1: 151-158. 10.3109/15622970009150584. 10.3109/15622970009150584

[18]

Kendell R, Jablensky A: Distinguishing between the validity and utility of psychiatric diagnoses. Am J Psychiatry. 2003, 160: 4-12. 10.1176/appi.ajp.160.1.4. 10.1176/appi.ajp.160.1.4

[19]

Hyman SH: Can neuroscience be integrated into the DSM-V?. Nature Rev Neurosc. 2007, 8: 725-732. 10.1038/nrn2218. 10.1038/nrn2218

[20]

Sanislow CA, Pine DS, Quinn KJ, Garvey MA, Heinssen RK, Wang PS, Cuthbert BN: Developing constructs for psychopathology research: Research Domain Criteria. J Abn Psychol. 2010, 119: 631-639. 10.1037/a0020909

[21]

Wong EHF, Yocca F, Smith MA, Lee C-M: Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters’ perspective. Int J Neuropsychopharm. 2010, 13: 1269-1284. 10.1017/S1461145710000866. 10.1017/s1461145710000866

[22]

Miller G: Is pharma running out of brainy ideas?. Science. 2010, 329: 481-482.

[23]

Schizophrenia AA: The drug deadlock. Nature. 2010, 468: 158-159. 10.1038/468158a. 10.1038/468158a

[24]

Mirnezami R, Nicholson J, Darzi A: Preparing for precision medicine. NEJM. 2012, 366: 489-491. 10.1056/NEJMp1114866. 10.1056/nejmp1114866

[25]

Food and Drug Administration: FDA approves Kalydeco to treat rare form of cystic fibrosis. 2012, Silver Spring, MD: FDA, [ http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm289633.htm ]

[26]

National Academy of Sciences: Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease. 2011, Washington, DC: National Academies Press

[27]

National Institute of Mental Health: The National Institute of Mental Health Strategic Plan. 2008, Bethesda, MD: National Institute of Mental Health, [ http://www.nimh.nih.gov/about/strategic-planning-reports/index.shtml ]

[28]

Davis M: Neural systems involved in fear and anxiety measured with fear-potentiated startle. Am Psychologist. 2006, 61: 741-756. 10.1037/0003-066x.61.8.741

[29]

Reconsidering anhedonia in depression: Lessons from translational neuroscience

Michael T. Treadway, David H. Zald

Neuroscience & Biobehavioral Reviews 2011 10.1016/j.neubiorev.2010.06.006

[30]

Wager TD, Smith EE: Neuroimaging studies of working memory: a meta-analysis. Cogn Affect Behav Neurosci. 2003, 3: 255-274. 10.3758/CABN.3.4.255. 10.3758/cabn.3.4.255

[31]

MacCorquodale K, Meehl PE: On a distinction between hypothetical constructs and intervening variables. Psychol Rev. 1948, 55: 95-107. 10.1037/h0056029

[32]

Krueger RF: The structure of common mental disorders. Arch Gen Psychiat. 1999, 56: 921-926. 10.1001/archpsyc.56.10.921. 10.1001/archpsyc.56.10.921

[33]

Hudziak JJ, Achenbach TM, Althoff RR, Pine DS: A dimensional approach to developmental psychopathology. Int J Methods Psychiat Res. 2007, 16: S16-S23. 10.1002/mpr.217. 10.1002/mpr.217

[34]

Gold JM, Barch DM, Carter CS, Dakin S, Luck SJ, MacDonald AW, Ragland JD, Ranganath C, Kovacs I, Silverstein SM, Strauss M, Strauss M: Clinical, functional, and intertask correlations of measures developed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia Consortium. Schizophr Bull. 2012, 38: 144-152. 10.1093/schbul/sbr142. 10.1093/schbul/sbr142

[35]

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

Aram V. Chobanian

JAMA 2003 10.1001/jama.289.19.2560

Cited By

2,288

Developmental influences on neural responses to emotional stimuli: The role of family history, parental bonding, and adverse childhood experiences

Romina Angeleri, Michele Grassi · 2026

Journal of Affective Disorders

Social anxiety and the positive valence system: A scoping review

Franklin Schneier, Isaac Deitz-Green · 2026

Journal of Mood & Anxiety Disor...

Transdiagnostic functional connectome signature of anhedonia relates to neurotransmitter and genetic profiles

Xuanyi Wang, Jie Shao · 2026

Journal of Affective Disorders

Transdiagnostic and Contextual Assessment of Addictive Behaviors

Alba González-Roz, Clara Iza-Fernández · 2025

Papeles del Psicólogo - Psychologis...

Exploring functional connectivity in clinical and data-driven groups of preterm and term adults

Laila Hadaya, František Váša · 2025

Brain Communications

Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice

Hubertus Himmerich, Janet Treasure · 2024

Trends in Molecular Medicine

Affective forecasting and psychopathology: A scoping review

Jala Rizeq · 2024

Clinical Psychology Review

Autism spectrum disorder in ICD-11—a critical reflection of its possible impact on clinical practice and research

Inge Kamp-Becker · 2024

Molecular Psychiatry

Burnout, Depression, and Diminished Well-Being among Physicians

Constance Guille, Srijan Sen · 2024

New England Journal of Medicine

The ChAMP App: A Scalable mHealth Technology for Detecting Digital Phenotypes of Early Childhood Mental Health

Bryn C. Loftness, Julia Halvorson-Phelan · 2024

IEEE Journal of Biomedical and Heal...

Striatal stimulation enhances cognitive control and evidence processing in rodents and humans

Adriano E. Reimer, Evan M. Dastin-van Rijn · 2024

Science Translational Medicine

Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Major and Persistent Depressive Disorders

Heather J. Walter, A. Reese Abright · 2023

Journal of the American Academy of...

Personality change in a trial of psilocybin therapy v. escitalopram treatment for depression

Brandon Weiss, Induni Ginige · 2023

Psychological Medicine

Clinical Trajectories in Adolescents with and without a History of Non-Suicidal Self-Injury: The BRIDGES Longitudinal Study

· 2023

Journal of Psychiatry and Brain Sci...

Modality-specific associations between sensory differences and autistic traits

Peter Bang, Kajsa Igelström · 2023

Autism

Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity

Alik S. Widge · 2023

Neuropsychopharmacology

Understanding the Error in Psychopathology: Notable Intraindividual Differences in Neural Variability of Performance Monitoring

Peter E. Clayson, Harold A. Rocha · 2022

Biological Psychiatry: Cognitive Ne...

The normative modeling framework for computational psychiatry

Saige Rutherford, Seyed Mostafa Kia · 2022

Nature Protocols

Promises and pitfalls of deep neural networks in neuroimaging-based psychiatric research

Fabian Eitel, Marc-André Schulz · 2021

Experimental Neurology

Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders

Duncan E. Astle, Joni Holmes · 2021

Journal of Child Psychology and Psy...

Metrics

2,288

Citations

35

References

Details

Published: May 14, 2013
Vol/Issue: 11(1)
License: View

Authors

Cite This Article

Bruce N Cuthbert, Thomas R Insel (2013). Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Medicine, 11(1). https://doi.org/10.1186/1741-7015-11-126

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

You May Also Like