Bone regeneration: current concepts and future directions

Rozalia Dimitriou; Elena Jones; Dennis McGonagle; Peter V Giannoudis

doi:10.1186/1741-7015-9-66

journal article May 31, 2011

Bone regeneration: current concepts and future directions

Rozalia Dimitriou Elena Jones

Dennis McGonagle Peter V Giannoudis

BMC Medicine Vol. 9 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/1741-7015-9-66

Abstract

AbstractBone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumour resection and skeletal abnormalities, or cases in which the regenerative process is compromised, including avascular necrosis, atrophic non-unions and osteoporosis. Currently, there is a plethora of different strategies to augment the impaired or 'insufficient' bone-regeneration process, including the 'gold standard' autologous bone graft, free fibula vascularised graft, allograft implantation, and use of growth factors, osteoconductive scaffolds, osteoprogenitor cells and distraction osteogenesis. Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible, to accelerate the overall regeneration process, or even to address systemic conditions, such as skeletal disorders and osteoporosis.

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Published: May 31, 2011
Vol/Issue: 9(1)
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Cite This Article

Rozalia Dimitriou, Elena Jones, Dennis McGonagle, et al. (2011). Bone regeneration: current concepts and future directions. BMC Medicine, 9(1). https://doi.org/10.1186/1741-7015-9-66

Bone regeneration: current concepts and future directions

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