Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development

Arindam Majumdar; Seppo Vainio; Andreas Kispert; Jill McMahon; Andrew P. McMahon

doi:10.1242/dev.00520

journal article Jul 15, 2003

Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development

Arindam Majumdar Seppo Vainio Andreas Kispert Jill McMahon

Andrew P. McMahon

Development Vol. 130 No. 14 pp. 3175-3185 · The Company of Biologists

View at Publisher Save 10.1242/dev.00520

Abstract

Reciprocal cell-cell interactions between the ureteric epithelium and the metanephric mesenchyme are needed to drive growth and differentiation of the embryonic kidney to completion. Branching morphogenesis of the Wolffian duct derived ureteric bud is integral in the generation of ureteric tips and the elaboration of the collecting duct system. Wnt11, a member of the Wnt superfamily of secreted glycoproteins, which have important regulatory functions during vertebrate embryonic development, is specifically expressed in the tips of the branching ureteric epithelium. In this work, we explore the role of Wnt11 in ureteric branching and use a targeted mutation of the Wnt11 locus as an entrance point into investigating the genetic control of collecting duct morphogenesis. Mutation of the Wnt11 gene results in ureteric branching morphogenesis defects and consequent kidney hypoplasia in newborn mice. Wnt11 functions, in part, by maintaining normal expression levels of the gene encoding glial cell-derived neurotrophic factor (Gdnf). Gdnf encodes a mesenchymally produced ligand for the Ret tyrosine kinase receptor that is crucial for normal ureteric branching. Conversely, Wnt11 expression is reduced in the absence of Ret/Gdnf signaling. Consistent with the idea that reciprocal interaction between Wnt11 and Ret/Gdnf regulates the branching process, Wnt11 and Ret mutations synergistically interact in ureteric branching morphogenesis. Based on these observations, we conclude that Wnt11 and Ret/Gdnf cooperate in a positive autoregulatory feedback loop to coordinate ureteric branching by maintaining an appropriate balance of Wnt11-expressing ureteric epithelium and Gdnf-expressing mesenchyme to ensure continued metanephric development.

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Details

Published: Jul 15, 2003
Vol/Issue: 130(14)
Pages: 3175-3185

Authors

A

Arindam Majumdar

Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA

S

Seppo Vainio

Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, FIN-90014, Oulu, Finland

A

Andreas Kispert

Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover,Carl-Neuberg-Strasse 1, 30625 Hannover, Germany

J

Jill McMahon

Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA

A

Andrew P. McMahon

Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA

Cite This Article

Arindam Majumdar, Seppo Vainio, Andreas Kispert, et al. (2003). Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development. Development, 130(14), 3175-3185. https://doi.org/10.1242/dev.00520

Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development

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