The
                    Drosophila
                    proneural gene
                    amos
                    promotes olfactory sensillum formation and suppresses bristle formation

Petra I. zur Lage; David R. A. Prentice; Eimear E. Holohan; Andrew P. Jarman

doi:10.1242/dev.00680

journal article Oct 01, 2003

The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation

Petra I. zur Lage David R. A. Prentice Eimear E. Holohan Andrew P. Jarman

Development Vol. 130 No. 19 pp. 4683-4693 · The Company of Biologists

View at Publisher Save 10.1242/dev.00680

Abstract

Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal. Having isolated the first specific amosloss-of-function mutations, we show definitively that amos is required to specify the precursors of two classes of olfactory sensilla. Unlike other known proneural mutations, a novel characteristic of amos loss of function is the appearance of ectopic sensory bristles in addition to loss of olfactory sensilla, owing to the inappropriate function of scute. This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes.

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Details

Published: Oct 01, 2003
Vol/Issue: 130(19)
Pages: 4683-4693
License: View

Authors

P

Petra I. zur Lage

The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK

D

David R. A. Prentice

The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK

E

Eimear E. Holohan

The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK

A

Andrew P. Jarman

The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK

Cite This Article

Petra I. zur Lage, David R. A. Prentice, Eimear E. Holohan, et al. (2003). The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation. Development, 130(19), 4683-4693. https://doi.org/10.1242/dev.00680

The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation

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