journal article Open Access Apr 15, 2014

The evolution and conservation of left-right patterning mechanisms

Development Vol. 141 No. 8 pp. 1603-1613 · The Company of Biologists
View at Publisher Save 10.1242/dev.100560
Abstract
Morphological asymmetry is a common feature of animal body plans, from shell coiling in snails to organ placement in humans. The signaling protein Nodal is key for determining this laterality. Many vertebrates, including humans, use cilia for breaking symmetry during embryonic development: rotating cilia produce a leftward flow of extracellular fluids that induces the asymmetric expression of Nodal. By contrast, Nodal asymmetry can be induced flow-independently in invertebrates. Here, we ask when and why flow evolved. We propose that flow was present at the base of the deuterostomes and that it is required to maintain organ asymmetry in otherwise perfectly bilaterally symmetrical vertebrates.
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Published
Apr 15, 2014
Vol/Issue
141(8)
Pages
1603-1613
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Cite This Article
Martin Blum, Kerstin Feistel, Thomas Thumberger, et al. (2014). The evolution and conservation of left-right patterning mechanisms. Development, 141(8), 1603-1613. https://doi.org/10.1242/dev.100560
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