The evolution and conservation of left-right patterning mechanisms

Martin Blum; Kerstin Feistel; Thomas Thumberger; Axel Schweickert

doi:10.1242/dev.100560

journal article Open Access Apr 15, 2014

The evolution and conservation of left-right patterning mechanisms

Martin Blum Kerstin Feistel

Thomas Thumberger Axel Schweickert

Development Vol. 141 No. 8 pp. 1603-1613 · The Company of Biologists

View at Publisher Save 10.1242/dev.100560

Abstract

Morphological asymmetry is a common feature of animal body plans, from shell coiling in snails to organ placement in humans. The signaling protein Nodal is key for determining this laterality. Many vertebrates, including humans, use cilia for breaking symmetry during embryonic development: rotating cilia produce a leftward flow of extracellular fluids that induces the asymmetric expression of Nodal. By contrast, Nodal asymmetry can be induced flow-independently in invertebrates. Here, we ask when and why flow evolved. We propose that flow was present at the base of the deuterostomes and that it is required to maintain organ asymmetry in otherwise perfectly bilaterally symmetrical vertebrates.

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Details

Published: Apr 15, 2014
Vol/Issue: 141(8)
Pages: 1603-1613
License: View

Authors

M

Martin Blum

Institute of Zoology, University of Hohenheim, 70593 Stuttgart, Germany

K

Kerstin Feistel

Institute of Zoology, University of Hohenheim, 70593 Stuttgart, Germany

T

Thomas Thumberger

Institute of Zoology, University of Hohenheim, 70593 Stuttgart, Germany

A

Axel Schweickert

Institute of Zoology, University of Hohenheim, 70593 Stuttgart, Germany

Cite This Article

Martin Blum, Kerstin Feistel, Thomas Thumberger, et al. (2014). The evolution and conservation of left-right patterning mechanisms. Development, 141(8), 1603-1613. https://doi.org/10.1242/dev.100560

The evolution and conservation of left-right patterning mechanisms

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