Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila

Pat Simpson

doi:10.1242/dev.109.3.509

journal article Jul 01, 1990

Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila

Pat Simpson

Development Vol. 109 No. 3 pp. 509-519 · The Company of Biologists

View at Publisher Save 10.1242/dev.109.3.509

Abstract

ABSTRACT
Cells in the neurectoderm of Drosophila face a choice between neural and epidermal fates. On the notum of the adult fly, neural cells differentiate sensory bristles in a precise pattern. Evidence has accumulated that the bristle pattern arises from the spatial distribution of small groups of cells, proneural clusters, from each of which a single bristle will result. One class of genes, which includes the genes of the achaete-scute complex, is responsible for the correct positioning of the proneural clusters. The cells of a proneural cluster constitute an equivalence group, each of them having the potential to become a neural cell. Only one cell, however, will adopt the primary, dominant, neural fate. This cell is selected by means of cellular interactions between the members of the group, since if the dominant cell is removed, one of the remaining, epidermal, cells will switch fates and become neural. The dominant cell therefore prevents the other cells of the group from becoming neural by a phenomenon known as lateral inhibition. They, then, adopt the secondary, epidermal, fate. A second class of genes, including the gene shaggy and the neurogenic genes mediate this process. There is some evidence that a proneural cluster is composed of a small number of cells, suggesting a contact-based mechanism of communication. The molecular nature of the protein products of the neurogenic genes is consistent with this idea.

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Details

Published: Jul 01, 1990
Vol/Issue: 109(3)
Pages: 509-519
License: View

Authors

P

Pat Simpson

Unité 184 de Biologie Moléculaire et de Génie Génétique de l′INSERM Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS , , Faculté de Médecine - II, rue Humann - 67085 STRASBOURG Cédex

Cite This Article

Pat Simpson (1990). Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. Development, 109(3), 509-519. https://doi.org/10.1242/dev.109.3.509

Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila

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