Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta

Carlos V. Cabrera

doi:10.1242/dev.110.1.733

journal article Sep 01, 1990

Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta

Carlos V. Cabrera

Development Vol. 110 No. 1 pp. 733-742 · The Company of Biologists

View at Publisher Save 10.1242/dev.110.1.733

Abstract

Abstract
A comparison of the patterns of expression of AS-C (T3) RNA and protein suggests that an important level of regulation occurs post-transcriptionally. First, when the RNA is abundant in the early embryo the protein is barely detectable. Later, the protein starts to accumulate in only a subset of the nuclei of those cells expressing the RNA. Only the cells in the subsets become the neuroblasts. This post-transcriptional regulation is suppressed in embryos mutant for the genes Notch and Delta; where all cells expressing RNA accumulate protein. These findings suggest that deployment of T3 protein expression is one of the causal factors that assigns specific fates to the neuroblasts and, in consequence, a basis for the mechanism of lateral inhibition is proposed.

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Metrics

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Citations

46

References

Details

Published: Sep 01, 1990
Vol/Issue: 110(1)
Pages: 733-742
License: View

Authors

C

Carlos V. Cabrera

MRC, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

Cite This Article

Carlos V. Cabrera (1990). Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta. Development, 110(1), 733-742. https://doi.org/10.1242/dev.110.1.733

Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta

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