Proneural clusters: equivalence groups in the epithelium of Drosophila

Pat Simpson; Cathie Carteret

doi:10.1242/dev.110.3.927

journal article Nov 01, 1990

Proneural clusters: equivalence groups in the epithelium of Drosophila

Pat Simpson Cathie Carteret

Development Vol. 110 No. 3 pp. 927-932 · The Company of Biologists

View at Publisher Save 10.1242/dev.110.3.927

Abstract

Abstract
The segregation of neural precursors from epidermal cells during development of the nervous system of Drosophila relies on interactions between cells that are thought to be initially equivalent. During development of the adult peripheral nervous system, failure of the cellular interactions leads to the differentiation of a tuft of sensory bristles at the site where usually only one develops. It is thus thought that a group of cells at that site (a proneural cluster) has the potential to make a bristle but that in normal development only one cell will do so. The question addressed here is do these cells constitute an equivalence group (Kimble, J., Sulston, J. and White, J. (1979). In Cell Lineage, Stem Cells and Cell Determination (ed. N. Le Douarin). Inserm Symposium No. 10 pp. 59–68, Elsevier, Amsterdam)? Within clusters mutant for shaggy, where several cells of a cluster follow the neural fate and differentiate bristles, it is shown that these display identical neuronal specificity: stimulation of the bristles evoke the same leg cleaning response and backfilling of single neurons reveal similar axonal projections in the central nervous system. This provides direct experimental evidence that the cells of a proneural cluster are developmentally equivalent.

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The choice of cell fate in the epidermis of Drosophila

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Metrics

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Citations

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References

Details

Published: Nov 01, 1990
Vol/Issue: 110(3)
Pages: 927-932
License: View

Authors

P

Pat Simpson

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l’INSERM, Faculté de Médecine -11, rue Humann - 67085 STRASBOURG Cédex, France

C

Cathie Carteret

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l’INSERM, Faculté de Médecine -11, rue Humann - 67085 STRASBOURG Cédex, France

Cite This Article

Pat Simpson, Cathie Carteret (1990). Proneural clusters: equivalence groups in the epithelium of Drosophila. Development, 110(3), 927-932. https://doi.org/10.1242/dev.110.3.927

Proneural clusters: equivalence groups in the epithelium of Drosophila

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