A local Wnt-3a signal is required for development of the mammalian hippocampus

Scott M. K. Lee; Shubha Tole; Elizabeth A. Grove; Andrew P. McMahon

doi:10.1242/dev.127.3.457

journal article Feb 01, 2000

A local Wnt-3a signal is required for development of the mammalian hippocampus

Scott M. K. Lee Shubha Tole

Elizabeth A. Grove Andrew P. McMahon

Development Vol. 127 No. 3 pp. 457-467 · The Company of Biologists

View at Publisher Save 10.1242/dev.127.3.457

Abstract

ABSTRACT
The mechanisms that regulate patterning and growth of the developing cerebral cortex remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes are expressed in selective patterns in the embryonic cortex. We have examined the role of Wnt-3a signaling at the caudomedial margin of the developing cerebral cortex, the site of hippocampal development. We show that Wnt-3a acts locally to regulate the expansion of the caudomedial cortex, from which the hippocampus develops. In mice lacking Wnt-3a, caudomedial cortical progenitor cells appear to be specified normally, but then underproliferate. By mid-gestation, the hippocampus is missing or represented by tiny populations of residual hippocampal cells. Thus, Wnt-3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development.

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Details

Published: Feb 01, 2000
Vol/Issue: 127(3)
Pages: 457-467
License: View

Authors

S

Scott M. K. Lee

Harvard University 1 Department of Molecular and Cellular Biology, The Biolabs , , 16 Divinity Avenue, Cambridge, MA 02138, USA

S

Shubha Tole

University of Chicago 2 Department of Neurobiology, Pharmacology and Physiology, Committees on Developmental Biology and Neurobiology, and Pritzker School of Medicine , , Chicago, IL 60637, USA

E

Elizabeth A. Grove

University of Chicago 2 Department of Neurobiology, Pharmacology and Physiology, Committees on Developmental Biology and Neurobiology, and Pritzker School of Medicine , , Chicago, IL 60637, USA

A

Andrew P. McMahon

Harvard University 1 Department of Molecular and Cellular Biology, The Biolabs , , 16 Divinity Avenue, Cambridge, MA 02138, USA

Cite This Article

Scott M. K. Lee, Shubha Tole, Elizabeth A. Grove, et al. (2000). A local Wnt-3a signal is required for development of the mammalian hippocampus. Development, 127(3), 457-467. https://doi.org/10.1242/dev.127.3.457

A local Wnt-3a signal is required for development of the mammalian hippocampus

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