Lycopene as a guardian of redox signalling.

Paola Palozza; Assunta Catalano; Rossella Simone; Achille Cittadini

doi:10.18388/abp.2012_2163

journal article Mar 17, 2012

Lycopene as a guardian of redox signalling.

Paola Palozza Assunta Catalano Rossella Simone Achille Cittadini

Acta Biochimica Polonica Vol. 59 No. 1 · Frontiers Media SA

View at Publisher Save 10.18388/abp.2012_2163

Abstract

It has been suggested that lycopene, the major carotenoid found in tomato, exhibits health-beneficial effects by virtue of its antioxidant activity. However, recent literature suggests that lycopene can actually "perform" roles independent of such capacity and involving a direct modulation of redox signalling. Reactive oxygen species are known to act as second messengers in the modulation of cellular signalling leading to gene expression changes and pharmacological responses. Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-κB and AP-1, Nrf2.

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Published: Mar 17, 2012
Vol/Issue: 59(1)

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Cite This Article

Paola Palozza, Assunta Catalano, Rossella Simone, et al. (2012). Lycopene as a guardian of redox signalling.. Acta Biochimica Polonica, 59(1). https://doi.org/10.18388/abp.2012_2163

Lycopene as a guardian of redox signalling.

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