Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl

Michele Barletta; Stephanie A. Kleine; Erik H. Hofmeister; Merrilee Thoresen; John F. Peroni; Heather K. Knych; Alexandra M. Scharf; Jane E. Quandt

doi:10.2460/ajvr.77.2.119

journal article Feb 01, 2016

Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl

Michele Barletta Stephanie A. Kleine Erik H. Hofmeister

Merrilee Thoresen

John F. Peroni Heather K. Knych Alexandra M. Scharf Jane E. Quandt

American Journal of Veterinary Research Vol. 77 No. 2 pp. 119-126 · American Veterinary Medical Association (AVMA)

View at Publisher Save 10.2460/ajvr.77.2.119

Abstract

Abstract

OBJECTIVE
To determine the minimum alveolar concentration that blunts adrenergic responses (MAC
BAR
) for isoflurane and evaluate effects of fentanyl on isoflurane MAC
BAR
in sheep.

ANIMALS
13 healthy adult Dorset-cross adult ewes.

PROCEDURES
In a crossover design, each ewe was anesthetized 2 times for determination of isoflurane MAC
BAR
. Anesthesia was induced with propofol administered IV. Sheep initially received fentanyl (5 μg/kg, IV, followed by a constant rate infusion of 5 μg/kg/h) or an equivalent volume of saline (0.9% NaCl) solution (control treatment). After a washout period of at least 8 days, the other treatment was administered. For MAC
BAR
determination, a mechanical nociceptive stimulus (ie, sponge forceps) was applied at the coronary band for 1 minute. The MAC
BAR
values of the 2 treatments were compared by means of a paired
t
test. During MAC
BAR
determination, blood samples were collected for measurement of plasma fentanyl concentration.

RESULTS
Mean ± SD isoflurane MAC
BAR
of the fentanyl and control treatments was 1.70 ± 0.28% and 1.79 ± 0.35%, respectively; no significant difference was found between the 2 treatments. Plasma concentration of fentanyl reached a median steady-state concentration of 1.69 ng/mL (interquartile range [25th to 75th percentile], 1.47 to 1.79 ng/mL), which was maintained throughout the study.

CONCLUSIONS AND CLINICAL RELEVANCE
Administration of fentanyl at 5 μg/kg, IV, followed by a constant rate infusion of the drug at 5 μg/kg/h did not decrease isoflurane MAC
BAR
. Further studies to determine the effect of higher doses of fentanyl on inhalation anesthetic agents and their potential adverse effects are warranted. (
Am J Vet Res
2016;77:119–126)

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Published: Feb 01, 2016
Vol/Issue: 77(2)
Pages: 119-126

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Cite This Article

Michele Barletta, Stephanie A. Kleine, Erik H. Hofmeister, et al. (2016). Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl. American Journal of Veterinary Research, 77(2), 119-126. https://doi.org/10.2460/ajvr.77.2.119

Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl

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