Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer

Sabina Galiniak; Mateusz Mołoń; Marek Biesiadecki; Agnieszka Mokrzyńska; Krzysztof Balawender

doi:10.3390/antiox12020277

journal article Open Access Jan 26, 2023

Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer

Sabina Galiniak

Mateusz Mołoń

Marek Biesiadecki Agnieszka Mokrzyńska Krzysztof Balawender

Antioxidants Vol. 12 No. 2 pp. 277 · MDPI AG

View at Publisher Save 10.3390/antiox12020277

Abstract

Oxidative stress is defined as an imbalanced state of the production of reactive oxygen species and antioxidant capacity that causes oxidative damage to biomolecules, leading to cell injury and finally death. Oxidative stress mediates the development and progression of several cancer diseases, including bladder cancer. The aim of our study was to determine markers of levels of the oxidative stress in serum and urine in the same patients in parallel in serum and urine. Furthermore, we tried to estimate the associations between oxidative stress markers and the type of cancer, its clinical stage and grade, as the well as correlations between serum and urinary markers in patients with bladder cancer. Sixty-one bladder cancer and 50 healthy volunteers as a control group were included. We determined the serum and urine levels of advanced oxidation protein products (AOPP), Amadori products, total antioxidant capacity, total oxidant status (TOS), oxidative status index (OSI), and malondialdehyde. We confirm that almost all markers are elevated in serum and urine from patients with bladder cancer than from healthy subjects. Moreover, we did not find differences in the level of oxidative stress markers and the type of tumor, its clinical stage, and grade. We noted correlations between serum and urinary biomarkers, in particular TOS and OSI. Our results clearly indicate the participation of oxidative stress in the development of bladder cancer.

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Details

Published: Jan 26, 2023
Vol/Issue: 12(2)
Pages: 277
License: View

Authors

S

Sabina Galiniak

Institute of Medical Sciences, Medical College, Rzeszow University, 35-310 Rzeszow, Poland

M

Mateusz Mołoń

Department of Biology, Institute of Biology and Biotechnology, Rzeszow University, 35-959 Rzeszow, Poland

M

Marek Biesiadecki

Institute of Medical Sciences, Medical College, Rzeszow University, 35-310 Rzeszow, Poland

A

Agnieszka Mokrzyńska

Department of Biology, Institute of Biology and Biotechnology, Rzeszow University, 35-959 Rzeszow, Poland

K

Krzysztof Balawender

Institute of Medical Sciences, Medical College, Rzeszow University, 35-310 Rzeszow, Poland

Cite This Article

Sabina Galiniak, Mateusz Mołoń, Marek Biesiadecki, et al. (2023). Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer. Antioxidants, 12(2), 277. https://doi.org/10.3390/antiox12020277

Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer

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