Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia

Rebeca Illescas-Montes; Víctor J. Costela-Ruiz; Lucía Melguizo-Rodríguez; Elvira De Luna-Bertos; Concepción Ruiz; Javier Ramos-Torrecillas

doi:10.3390/diagnostics11010063

journal article Open Access Jan 03, 2021

Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia

Rebeca Illescas-Montes

Víctor J. Costela-Ruiz Lucía Melguizo-Rodríguez Elvira De Luna-Bertos Concepción Ruiz

Javier Ramos-Torrecillas

Diagnostics Vol. 11 No. 1 pp. 63 · MDPI AG

View at Publisher Save 10.3390/diagnostics11010063

Abstract

Fibromyalgia (FM) is a highly prevalent syndrome that impairs the quality of life of the patients; however, its diagnosis is complex and mainly centered on pain symptoms. The study of salivary biomarkers has proven highly useful for the diagnosis and prognosis of numerous diseases. The objective of this review was to gather published data on the utilization of salivary biomarkers to facilitate and complement the diagnosis of FM. Salivary biomarkers used in FM diagnosis include cortisol; calgranulin; and the enzymes α-amylase, transaldolase, and phosphoglycerate mutase. Increased serum levels of C-reactive protein, cytokines interleukin 1-β, interleukin 6, interleukin 8, interleukin 10, interleukin 17, tumor necrosis factor α, and various chemokines may serve as salivary biomarkers, given observations of their increased serum levels in patients with FM. Further research is warranted to study in depth the role and performance of biomarkers currently used in FM diagnosis/prognosis and to identify novel salivary biomarkers for this disease.

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References

129

[1]

Smith "Large Candidate Gene Association Study Reveals Genetic Risk Factors and Therapeutic Targets for Fibromyalgia" Arthritis Rheum. (2012) 10.1002/art.33338

[2]

Borchers "Fibromyalgia: A Critical and Comprehensive Review" Clin. Rev. Allergy. Immunol. (2015) 10.1007/s12016-015-8509-4

[3]

McLean "Momentary Relationship between Cortisol Secretion and Symptoms in Patients with Fibromyalgia" Arthritis Rheum. (2005) 10.1002/art.21372

[4]

Ruggiero "A Preliminary Study on Serum Proteomics in Fibromyalgia Syndrome" Clin. Chem. Lab. Med. (CCLM) (2014) 10.1515/cclm-2014-0086

[5]

Mendieta "IL-8 and IL-6 Primarily Mediate the Inflammatory Response in Fibromyalgia Patients" J. Neuroimmunol. (2016) 10.1016/j.jneuroim.2015.11.011

[6]

Lee "Saliva: An Emerging Biofluid for Early Detection of Diseases" Am. J. Dent. (2009)

[7]

Zhang "Saliva in the Diagnosis of Diseases" Int. J. Oral Sci. (2016) 10.1038/ijos.2016.38

[8]

Melguizo-Rodríguez, L., Costela-Ruiz, V.J., Manzano-Moreno, F.J., Ruiz, C., and Illescas-Montes, R. (2020). Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies. Int. J. Mol. Sci., 21. 10.3390/ijms21145173

[9]

Laroche "Fibromyalgia" Rev. Prat. (2019)

[10]

Marques "Prevalence of Fibromyalgia: Literature Review Update" Rev. Bras. Reumatol. Engl. Ed. (2017) 10.1016/j.rbr.2016.10.004

[11]

Sluka "Neurobiology of Fibromyalgia and Chronic Widespread Pain" Neuroscience (2016) 10.1016/j.neuroscience.2016.06.006

[12]

Benlidayi "Role of Inflammation in the Pathogenesis and Treatment of Fibromyalgia" Rheumatol. Int. (2019) 10.1007/s00296-019-04251-6

[13]

Williams "Heterogeneity in Chronic Fatigue Syndrome—Empirically Defined Subgroups from the PACE Trial" Psychol. Med. (2017) 10.1017/s0033291716003615

[14]

Martini "Epidemiological, Pharmacological and Sociodemographic Characterisation of a Population of 386 Fibromyalgic Patients Referred to a Tertiary Pain Centre in Italy" Clin. Exp. Rheumatol. (2019)

[15]

Fietta "Fibromyalgia and Psychiatric Disorders" Acta Biomed. (2007)

[16]

Loganathan "Fibromyalgia, Sjogren’s & Depression: Linked?" Postgrad. Med. (2020) 10.1080/00325481.2020.1758426

[17]

Wilson "What Is Chronic Fatigue Syndrome? Heterogeneity within an International Multicentre Study" Aust. N. Z. J. Psychiatry (2001) 10.1046/j.1440-1614.2001.00888.x

[18]

Collin "Chronic Fatigue Syndrome (CFS) Symptom-Based Phenotypes in Two Clinical Cohorts of Adult Patients in the UK and The Netherlands" J. Psychosom. Res. (2016) 10.1016/j.jpsychores.2015.12.006

[19]

Cash "Mindfulness Meditation Alleviates Fibromyalgia Symptoms in Women: Results of a Randomized Clinical Trial" Ann. Behav. Med. (2015) 10.1007/s12160-014-9665-0

[20]

Neurogenic inflammation in fibromyalgia

Geoffrey Littlejohn, Emma Guymer

Seminars in Immunopathology 2018 10.1007/s00281-018-0672-2

[21]

Chinn "Fibromyalgia Pathogenesis and Treatment Options Update" Curr. Pain Headache Rep. (2016) 10.1007/s11916-016-0556-x

[22]

Rus "Insight into the Biological Pathways Underlying Fibromyalgia by a Proteomic Approach" J. Proteom. (2018) 10.1016/j.jprot.2018.07.009

[23]

Choi "Prevalence and Clinical Impact of Fibromyalgia in Patients with Primary Sjögren’s Syndrome" Clin. Exp. Rheumatol. (2016)

[24]

EULAR revised recommendations for the management of fibromyalgia

G J Macfarlane, C Kronisch, L E Dean et al.

Annals of the Rheumatic Diseases 2017 10.1136/annrheumdis-2016-209724

[25]

Talotta "One Year in Review 2017: Fibromyalgia" Clin. Exp. Rheumatol. (2017)

[26]

Wolfe "Editorial: The Status of Fibromyalgia Criteria" Arthritis Rheumatol. (2015) 10.1002/art.38908

[27]

Mas "EPISER Study Group Prevalence and Impact of Fibromyalgia on Function and Quality of Life in Individuals from the General Population: Results from a Nationwide Study in Spain" Clin. Exp. Rheumatol. (2008)

[28]

"Fibromyalgia: Prevalence, Epidemiologic Profiles and Economic Costs" Med. Clin. (Barc) (2017) 10.1016/j.medcli.2017.06.008

[29]

Wolfe "The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia" Arthritis Rheum. (1990) 10.1002/art.1780330203

[30]

Wolfe "The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity" Arthritis Care Res. (2010) 10.1002/acr.20140

[31]

Yi "Mini-Review Article—Current Opinion on Salivary Biomarkers as a Measurement for Stress and Fatigue" Open Biomark. J. (2013) 10.2174/1875318301306010009

[32]

Catley "A Naturalistic Evaluation of Cortisol Secretion in Persons with Fibromyalgia and Rheumatoid Arthritis" Arthritis Care Res. (2000) 10.1002/1529-0131(200002)13:1<51::aid-art8>3.0.co;2-q

[33]

Stress exacerbates pain in the everyday lives of women with fibromyalgia syndrome—The role of cortisol and alpha-amylase

Susanne Fischer, Johanna M. Doerr, Jana Strahler et al.

Psychoneuroendocrinology 2016 10.1016/j.psyneuen.2015.09.018

[34]

Borghi "Massage Therapy in Cortisol Circadian Rhythm, Pain Intensity, Perceived Stress Index and Quality of Life of Fibromyalgia Syndrome Patients" Complementary Ther. Clin. Pract. (2018) 10.1016/j.ctcp.2017.12.006

[35]

Moraes "A Systematic Review of Psychoneuroimmunology-Based Interventions" Psychol. Health Med. (2018) 10.1080/13548506.2017.1417607

[36]

Wingenfeld "Salivary Cortisol Release and Hypothalamic Pituitary Adrenal Axis Feedback Sensitivity in Fibromyalgia Is Associated with Depression but Not with Pain" J. Pain (2010) 10.1016/j.jpain.2010.02.011

[37]

Coppens "Cortisol and Subjective Stress Responses to Acute Psychosocial Stress in Fibromyalgia Patients and Control Participants" Psychosom. Med. (2018) 10.1097/psy.0000000000000551

[38]

Tak "Meta-Analysis and Meta-Regression of Hypothalamic-Pituitary-Adrenal Axis Activity in Functional Somatic Disorders" Biol. Psychol. (2011) 10.1016/j.biopsycho.2011.02.002

[39]

Riva "Fibromyalgia Syndrome Is Associated with Hypocortisolism" Int.J. Behav. Med. (2010) 10.1007/s12529-010-9097-6

[40]

Wingenfeld "HPA Axis Reactivity and Lymphocyte Glucocorticoid Sensitivity in Fibromyalgia Syndrome and Chronic Pelvic Pain" Psychosom. Med. (2008) 10.1097/psy.0b013e31815ff3ce

[41]

"Has Catechol-O-Methyltransferase Genotype (Val158Met) an Influence on Endocrine, Sympathetic Nervous and Humoral Immune Systems in Women with Fibromyalgia Syndrome?" Clin. J. Pain (2014) 10.1097/ajp.0b013e3182928da0

[42]

Escolano "Niveles de α-Amilasa seriada salival en mujeres con fibromialgia" Cuad. Med. Psicosomática Psiquiatr. Enlace (2014)

[43]

Lamo "Psicobioquimica (Estrés, Ansiedad y Depresión) En Fibromialgia" Cuad. Monográficos Psicobioquimica (2014)

[44]

Skoluda "The Role of Week(End)-Day and Awakening Time on Cortisol and Alpha-Amylase Awakening Responses" Stress (2016) 10.1080/10253890.2016.1174850

[45]

Shahriari "The Relationship between the Level of Salivary Alpha Amylase Activity and Pain Severity in Patients with Symptomatic Irreversible Pulpitis" Restor. Dent. Endod. (2013) 10.5395/rde.2013.38.3.141

[46]

Vahedi "The Relationship Between Salivary Alpha Amylase Activity and Score of McGill Pain Questionnaire in Patients with Tension Type Headache" Basic Clin. Neurosci. (2018) 10.29252/nirp.bcn.9.1.59

[47]

Bazzichi "Detection of Potential Markers of Primary Fibromyalgia Syndrome in Human Saliva" Proteom. Clin. Appl. (2009) 10.1002/prca.200900076

[48]

Putative salivary biomarkers useful to differentiate patients with fibromyalgia

Federica Ciregia, Camillo Giacomelli, Laura Giusti et al.

Journal of Proteomics 2019 10.1016/j.jprot.2018.04.012

[49]

Bazzichi "A Multidisciplinary Approach to Study the Effects of Balneotherapy and Mud-Bath Therapy Treatments on Fibromyalgia" Clin. Exp. Rheumatol. (2013)

[50]

Giacomelli "MALDI-TOF and SELDI-TOF Analysis: “Tandem” Techniques to Identify Potential Biomarker in Fibromyalgia" Reumatismo (2011) 10.4081/reumatismo.2011.165

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Published: Jan 03, 2021
Vol/Issue: 11(1)
Pages: 63
License: View

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Rebeca Illescas-Montes