The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study

Pierre Déchelotte; Jonathan Breton; Clémentine Trotin-Picolo; Barbara Grube; Constantin Erlenbeck; Gordana Bothe; Sergueï O. Fetissov; Gregory Lambert

doi:10.3390/nu13061902

journal article Open Access Jun 01, 2021

The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study

Pierre Déchelotte

Jonathan Breton Clémentine Trotin-Picolo Barbara Grube Constantin Erlenbeck Gordana Bothe Sergueï O. Fetissov

Gregory Lambert

Nutrients Vol. 13 No. 6 pp. 1902 · MDPI AG

View at Publisher Save 10.3390/nu13061902

Abstract

Background: Increasing evidence supports the role of the gut microbiota in the control of body weight and feeding behavior. Moreover, recent studies have reported that the probiotic strain Hafnia alvei HA4597® (HA), which produces the satietogenic peptide ClpB mimicking the effect of alpha-MSH, reduced weight gain and adiposity in rodent models of obesity. Methods: To investigate the clinical efficacy of HA, 236 overweight subjects were included, after written informed consent, in a 12-week prospective, double-blind, randomized study. All subjects received standardized counselling for a −20% hypocaloric diet and were asked to maintain their usual physical activity. Subjects of the HA group received two capsules per day providing 100 billion bacteria per day and subjects in the Placebo (P) group received two placebo capsules. The primary endpoint was the percentage of subjects achieving a weight loss of at least 3% after 12 weeks. Intention-to-treat statistical analysis was performed using exact-Fischer, Mann-Whitney and paired-Wilcoxon tests as appropriate. Results: In the HA group, significantly more subjects (+33%) met the primary endpoint than in the P group (54.9 vs. 41.4%, p = 0.048). In the HA group, an increased feeling of fullness (p = 0.009) and a greater loss of hip circumference (p < 0.001) at 12 weeks were also observed. Fasting glycemia at 12 weeks was significantly lower (p < 0.05) in the HA compared to P group. Clinical and biological tolerance was good in both groups. Conclusions: A 12-week treatment with the probiotic strain H. alvei HA4597® significantly improves weight loss, feeling of fullness and reduction of hip circumference in overweight subjects following moderate hypocaloric diet. These data support the use of H. alvei HA4597® in the global management of excess weight.

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Effect of a Probiotic and a Synbiotic on Body Fat Mass, Body Weight and Traits of Metabolic Syndrome in Individuals with Abdominal Overweight: A Human, Double-Blind, Randomised, Controlled Clinical Study

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References

Details

Published: Jun 01, 2021
Vol/Issue: 13(6)
Pages: 1902
License: View

Authors

P

Pierre Déchelotte

Inserm UMR 1073, 76000 Rouen, France; Nutrition Department, University Hospital, 76000 Rouen, France; Department of Biology, Rouen Normandy University, 76130 Mont-Saint-Aignan, France

J

Jonathan Breton

Inserm UMR 1073, 76000 Rouen, France; Nutrition Department, University Hospital, 76000 Rouen, France; Department of Biology, Rouen Normandy University, 76130 Mont-Saint-Aignan, France

C

Clémentine Trotin-Picolo

TargEDys SA, 91160 Longjumeau, France

B

Barbara Grube

Practice for General Medicine, 12169 Berlin, Germany

C

Constantin Erlenbeck

Analyze & Realize GmbH, 13467 Berlin, Germany

G

Gordana Bothe

Analyze & Realize GmbH, 13467 Berlin, Germany

S

Sergueï O. Fetissov

Department of Biology, Rouen Normandy University, 76130 Mont-Saint-Aignan, France; Inserm UMR 1239, 76130 Mont-Saint-Aignan, France

G

Gregory Lambert

TargEDys SA, 91160 Longjumeau, France

Cite This Article

Pierre Déchelotte, Jonathan Breton, Clémentine Trotin-Picolo, et al. (2021). The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study. Nutrients, 13(6), 1902. https://doi.org/10.3390/nu13061902

The Probiotic Strain H. alvei HA4597® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study

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