Chitosan-Based Electrochemical Sensors for Pharmaceuticals and Clinical Applications

Alexandra Virginia Bounegru; Iulian Bounegru

doi:10.3390/polym15173539

journal article Open Access Aug 25, 2023

Chitosan-Based Electrochemical Sensors for Pharmaceuticals and Clinical Applications

Alexandra Virginia Bounegru

Iulian Bounegru

Polymers Vol. 15 No. 17 pp. 3539 · MDPI AG

View at Publisher Save 10.3390/polym15173539

Abstract

Chitosan (CTS), a biocompatible and multifunctional material derived from chitin, has caught researchers’ attention in electrochemical detection due to its unique properties. This review paper provides a comprehensive overview of the recent progress and applications of CTS-based electrochemical sensors in the analysis of pharmaceutical products and other types of samples, with a particular focus on the detection of medicinal substances. The review covers studies and developments from 2003 to 2023, highlighting the remarkable properties of CTS, such as biocompatibility, chemical versatility, and large surface area, that make it an excellent candidate for sensor modification. Combining CTS with various nanomaterials significantly enhances the detection capabilities of electrochemical sensors. Various types of CTS-based sensors are analyzed, including those utilizing carbon nanomaterials, metallic nanoparticles, conducting polymers, and molecularly imprinted CTS. These sensors exhibit excellent sensitivity, selectivity, and stability, enabling the precise and reliable detection of medications. The manufacturing strategies used for the preparation of CTS-based sensors are described, the underlying detection mechanisms are elucidated, and the integration of CTS sensors with transducer systems is highlighted. The prospects of CTS-based electrochemical sensors are promising, with opportunities for miniaturization, simultaneous detection, and real-time monitoring applications.

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References

119

[1]

Beccaria "Current Developments in LC-MS for Pharmaceutical Analysis" Analyst (2020) 10.1039/c9an02145k

[2]

Deng "Residue Analysis of the Pharmaceutical Diclofenac in Different Water Types Using ELISA and GC−MS" Environ. Sci. Technol. (2003) 10.1021/es0341945

[3]

Yabré, M., Ferey, L., Somé, I., and Gaudin, K. (2018). Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis. Molecules, 23. 10.3390/molecules23051065

[4]

Krait "Advances of Capillary Electrophoresis Enantioseparations in Pharmaceutical Analysis (2017–2020)" Electrophoresis (2021) 10.1002/elps.202000359

[5]

Soleymani "Advanced Materials for Immunosensing of Pharmaceutical and Drug Compounds" ImmunoAnalysis (2021) 10.34172/ia.2021.05

[6]

Annu "Recent Development in Chitosan-Based Electrochemical Sensors and Its Sensing Application" Int. J. Biol. Macromol. (2020) 10.1016/j.ijbiomac.2020.09.012

[7]

Seger "Usage and Limitations of Liquid Chromatography-Tandem Mass Spectrometry (LC–MS/MS) in Clinical Routine Laboratories" Med. Wochenschr. (2012) 10.1007/s10354-012-0147-3

[8]

Mollarasouli "Magnetic Nanoparticles in Developing Electrochemical Sensors for Pharmaceutical and Biomedical Applications" Talanta (2021) 10.1016/j.talanta.2021.122108

[9]

Micro- and nano-devices for electrochemical sensing

Federica Mariani, Isacco Gualandi, Wolfgang Schuhmann et al.

Microchimica Acta 2022 10.1007/s00604-022-05548-3

[10]

Prabhu "Reviewing the Use of Chitosan and Polydopamine for Electrochemical Sensing" Curr. Opin. Electrochem. (2022) 10.1016/j.coelec.2021.100885

[11]

A review on chitosan and chitosan-based bionanocomposites: Promising material for combatting global issues and its applications

Motia Azmana, Syed Mahmood, Ayah Rebhi Hilles et al.

International Journal of Biological Macromolecules 2021 10.1016/j.ijbiomac.2021.07.023

[12]

Shukla "The Effect of Loading Carbon Nanotubes onto Chitosan Films on Electrochemical Dopamine Sensing in the Presence of Biological Interference" Talanta (2018) 10.1016/j.talanta.2017.12.081

[13]

Pandikumar, A., and Rameshkumar, P. (2019). Graphene-Based Electrochemical Sensors for Biomolecules, Elsevier. Micro and Nano Technologies.

[14]

Santos "Simultaneous Determination of Salbutamol and Propranolol in Biological Fluid Samples Using an Electrochemical Sensor Based on Functionalized-Graphene, Ionic Liquid and Silver Nanoparticles" J. Electroanal. Chem. (2018) 10.1016/j.jelechem.2018.07.018

[15]

Karrat "Recent Advances in Chitosan-Based Electrochemical Sensors and Biosensors" J. Chem. Environ. Res. (2020)

[16]

Zahed "Silver Nanoparticles Decorated Polyaniline Nanocomposite Based Electrochemical Sensor for the Determination of Anticancer Drug 5-Fluorouracil" J. Pharm. Biomed. Anal. (2018) 10.1016/j.jpba.2018.08.004

[17]

Yang, Q., and Fukamizo, T. (2019). Targeting Chitin-Containing Organisms, Springer. Advances in Experimental Medicine and Biology. 10.1007/978-981-13-7318-3

[18]

"An Approach to Understanding the Deacetylation Degree of Chitosan" Carbohydr. Polym. (2010) 10.1016/j.carbpol.2010.01.037

[19]

Zargar "A Review on Chitin and Chitosan Polymers: Structure, Chemistry, Solubility, Derivatives, and Applications" ChemBioEng Rev. (2015) 10.1002/cben.201400025

[20]

Suginta "Electrochemical Biosensor Applications of Polysaccharides Chitin and Chitosan" Chem. Rev. (2013) 10.1021/cr300325r

[21]

Broek, L.A.M., and Boeriu, C.G. (2019). Chitin and Chitosan, Wiley. 10.1002/9781119450467

[22]

Petrucci, R., Pasquali, M., Scaramuzzo, F.A., and Curulli, A. (2021). Recent Advances in Electrochemical Chitosan-Based Chemosensors and Biosensors: Applications in Food Safety. Chemosensors, 9. 10.20944/preprints202106.0700.v1

[23]

Shafi "Antimicrobial and Antioxidant Properties of Chitosan and Its Derivatives and Their Applications: A Review" Int. J. Biol. Macromol. (2020) 10.1016/j.ijbiomac.2020.08.153

[24]

Dhanavel "Preparation and Characterization of Cross-Linked Chitosan/Palladium Nanocomposites for Catalytic and Antibacterial Activity" J. Mol. Liq. (2018) 10.1016/j.molliq.2018.02.076

[25]

Gill "A Novel Copper-Based 3D Porous Nanocomposite for Electrochemical Detection and Inactivation of Pathogenic Bacteria" Sens. Actuators B Chem. (2020) 10.1016/j.snb.2020.128449

[26]

Mittal "Recent Progress in the Structural Modification of Chitosan for Applications in Diversified Biomedical Fields" Eur. Polym. J. (2018) 10.1016/j.eurpolymj.2018.10.013

[27]

Shi "Functionalization of Nanocellulose Applied with Biological Molecules for Biomedical Application: A Review" Carbohydr. Polym. (2022) 10.1016/j.carbpol.2022.119208

[28]

Li "Ultrasensitive, Label-Free Voltammetric Determination of Norfloxacin Based on Molecularly Imprinted Polymers and Au Nanoparticle-Functionalized Black Phosphorus Nanosheet Nanocomposite" J. Hazard. Mater. (2022) 10.1016/j.jhazmat.2022.129107

[29]

Li "Molecularly Imprinted Polypyrrole Film-Coated Poly(3,4-Ethylenedioxythiophene): Polystyrene Sulfonate-Functionalized Black Phosphorene for the Selective and Robust Detection of Norfloxacin" Mater. Today Chem. (2022) 10.1016/j.mtchem.2022.101043

[30]

Advanced growth of 2D MXene for electrochemical sensors

Nadeem Hussain Solangi, Nabisab Mujawar Mubarak, Rama Rao Karri et al.

Environmental Research 2023 10.1016/j.envres.2023.115279

[31]

Wang "Molecularly Imprinted Polymer (MIP) Based Electrochemical Sensors and Their Recent Advances in Health Applications" Sens. Actuators Rep. (2023) 10.1016/j.snr.2023.100153

[32]

Labuda "Terminology of Electrochemical Methods of Analysis (IUPAC Recommendations 2019)" Pure Appl. Chem. (2020) 10.1515/pac-2018-0109

[33]

Wang, J. (2006). Analytical Electrochemistry, Wiley. 10.1002/0471790303

[34]

Yan "Advanced Functional Electroactive and Photoactive Materials for Monitoring the Environmental Pollutants" Adv. Funct. Mater. (2021) 10.1002/adfm.202008227

[35]

Simões, F.R., and Xavier, M.G. (2017). Nanoscience and Its Applications, Elsevier.

[36]

Hussain, C.M., and Kailasa, S.K. (2021). Handbook of Nanomaterials for Sensing Applications, Elsevier. Micro and Nano Technologies.

[37]

Lee "A Short Review on Chitosan Membrane for Biomolecules Immobilization" J. Mol. Genet. Med. (2015)

[38]

Device integration of electrochemical biosensors

Jie Wu, Hong Liu, Weiwei Chen et al.

Nature Reviews Bioengineering 2023 10.1038/s44222-023-00032-w

[39]

Zhong "Current Progress of Nanomaterials in Molecularly Imprinted Electrochemical Sensing" Crit. Rev. Anal. Chem. (2018) 10.1080/10408347.2017.1360762

[40]

Rajpurohit "Simultaneous Electrochemical Sensing of Three Prevalent Anti-Allergic Drugs Utilizing Nanostructured Manganese Hexacyanoferrate/Chitosan Modified Screen Printed Electrode" Sens. Actuators B Chem. (2019) 10.1016/j.snb.2019.05.046

[41]

Gholivand "Cetirizine Dihydrochloride Sensor Based on Nano Composite Chitosan, MWCNTs and Ionic Liquid" Microchem. J. (2019) 10.1016/j.microc.2019.01.068

[42]

Rizwan "AuNPs/CNOs/SWCNTs/Chitosan-Nanocomposite Modified Electrochemical Sensor for the Label-Free Detection of Carcinoembryonic Antigen" Biosens. Bioelectron. (2018) 10.1016/j.bios.2018.02.037

[43]

Tabasi "Reduced Graphene Oxide-Chitosan-Aptamer Interface as New Platform for Ultrasensitive Detection of Human Epidermal Growth Factor Receptor 2" Biosens. Bioelectron. (2017) 10.1016/j.bios.2017.04.020

[44]

Pannell "Versatile Sarcosine and Creatinine Biosensing Schemes Utilizing Layer-by-Layer Construction of Carbon Nanotube-Chitosan Composite Films" J. Electroanal. Chem. (2018) 10.1016/j.jelechem.2018.02.023

[45]

Kushwaha "Electrochemical Sensing of Paracetamol Using Iron Oxide Encapsulated in Chitosan-Grafted-Polyaniline" ACS Appl. Polym. Mater. (2020) 10.1021/acsapm.0c00239

[46]

Abd-Elsabour, M., Abou-Krisha, M.M., Kenawy, S.H., and Yousef, T.A. (2023). A Novel Electrochemical Sensor Based on an Environmentally Friendly Synthesis of Magnetic Chitosan Nanocomposite Carbon Paste Electrode for the Determination of Diclofenac to Control Inflammation. Nanomaterials, 13. 10.3390/nano13061079

[47]

Wong "Square-Wave Voltammetric Determination of Clindamycin Using a Glassy Carbon Electrode Modified with Graphene Oxide and Gold Nanoparticles within a Crosslinked Chitosan Film" Sens. Actuators B Chem. (2016) 10.1016/j.snb.2016.03.014

[48]

Wu "An Electrochemical Sensor Based on Synergistic Enhancement Effects between Nitrogen-Doped Carbon Nanotubes and Copper Ions for Ultrasensitive Determination of Anti-Diabetic Metformin" Sci. Total Environ. (2023) 10.1016/j.scitotenv.2023.163120

[49]

Zaimbashi "An Electrochemical Sensing Platform Based on a Modified Carbon Paste Electrode with Graphene/Co3O4 Nanocomposite for Sensitive Propranolol Determination" ADMET DMPK (2023)

[50]

Feroz "A Novel Molecular Imprinted Polymer Layer Electrode for Enhanced Sensitivity Electrochemical Determination of the Antidepressant Fluoxetine" J. Electroanal. Chem. (2020) 10.1016/j.jelechem.2020.114693

Showing 50 of 119 references

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Details

Published: Aug 25, 2023
Vol/Issue: 15(17)
Pages: 3539
License: View

Authors

A

Alexandra Virginia Bounegru

Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunărea de Jos” University of Galati, 47 Domnească Street, 800008 Galati, Romania

I

Iulian Bounegru

Competences Centre: Interfaces-Tribocorrosion-Electrochemical Systems, “Dunărea de Jos” University of Galati, 47 Domnească Street, 800008 Galati, Romania; Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galati, 35 Al. I. Cuza Street, 800010 Galati, Romania

Cite This Article

Alexandra Virginia Bounegru, Iulian Bounegru (2023). Chitosan-Based Electrochemical Sensors for Pharmaceuticals and Clinical Applications. Polymers, 15(17), 3539. https://doi.org/10.3390/polym15173539

Chitosan-Based Electrochemical Sensors for Pharmaceuticals and Clinical Applications

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