Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Saeid Mezail Mawazi; Mohit Kumar; Noraini Ahmad; Yi Ge; Syed Mahmood

doi:10.3390/polym16101351

journal article Open Access May 10, 2024

Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Saeid Mezail Mawazi

Polymers Vol. 16 No. 10 pp. 1351 · MDPI AG

View at Publisher Save 10.3390/polym16101351

Abstract

Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse applications of chitosan and its derivatives in the antibacterial, anticancer, wound healing, and tissue engineering fields. In antibacterial applications, chitosan exhibits potent antimicrobial properties by disrupting microbial membranes and DNA, making it a promising natural preservative and agent against bacterial infections. Its role in cancer therapy involves the development of chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays a crucial role in wound healing by promoting cell proliferation, angiogenesis, and regulating inflammatory responses. Additionally, chitosan serves as a multifunctional scaffold in tissue engineering, facilitating the regeneration of diverse tissues such as cartilage, bone, and neural tissue by promoting cell adhesion and proliferation. The extensive range of applications for chitosan in pharmaceutical and biomedical sciences is not only highlighted by the comprehensive scope of this review, but it also establishes it as a fundamental component for forthcoming research in biomedicine.

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References

Details

Published: May 10, 2024
Vol/Issue: 16(10)
Pages: 1351
License: View

Authors

S

Saeid Mezail Mawazi

School of Pharmacy, Management and Science University, Shah Alam 40100, Selangor, Malaysia

M

Mohit Kumar

Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda 151001, Punjab, India

N

Noraini Ahmad

Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia

Y

Yi Ge

School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK

S

Syed Mahmood

Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia

Funding

Queen’s University Belfast

Cite This Article

Saeid Mezail Mawazi, Mohit Kumar, Noraini Ahmad, et al. (2024). Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields. Polymers, 16(10), 1351. https://doi.org/10.3390/polym16101351

Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

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