The prelimbic cortex muscarinic M3receptor–nitric oxide–guanylyl cyclase pathway modulates cardiovascular responses in rats

Aline Fassini; Leandro S. Antero; Fernando M.A. Corrêa; Sâmia R. Joca; Leonardo B.M. Resstel

doi:10.1002/jnr.23537

journal article Open Access Jan 16, 2015

The prelimbic cortex muscarinic M3receptor–nitric oxide–guanylyl cyclase pathway modulates cardiovascular responses in rats

Aline Fassini Leandro S. Antero Fernando M.A. Corrêa Sâmia R. Joca Leonardo B.M. Resstel

Journal of Neuroscience Research Vol. 93 No. 5 pp. 830-838 · Wiley

View at Publisher Save 10.1002/jnr.23537

Abstract

The prelimbic cortex (PL), a limbic structure, sends projections to areas involved in the control of cardiovascular responses. Stimulation of the PL with acetylcholine (ACh) evokes depressor and tachycardiac responses mediated by local PL muscarinic receptors. Early studies demonstrated that stimulation of muscarinic receptors induced nitric oxide (NO) synthesis and cyclic guanosine cyclic monophosphate (cGMP) formation. Hence, this study investigates which PL muscarinic receptor subtype is involved in the cardiovascular response induced by ACh and tests the hypothesis that cardiovascular responses caused by muscarinic receptor stimulation in the PL are mediated by local NO and cGMP formation. PL pretreatment with J104129 (an M3receptor antagonist) blocked the depressor and tachycardiac response evoked by injection of ACh into the PL. Pretreatment with either pirenzepine (an M1receptor antagonist) or AF‐DX 116 (an M2and M4receptor antagonist) did not affect cardiovascular responses evoked by ACh. Moreover, similarly to the antagonism of PL M3receptors, pretreatment with Nω‐propyl‐L‐arginine (an inhibitor of neuronal NO synthase), carboxy‐PTIO(S)‐3‐carboxy‐4‐hydroxyphenylglicine (an NO scavenger), or 1H‐[1,2,4]oxadiazolol‐[4,3‐a]quinoxalin‐1‐one (a guanylate cyclase inhibitor) blocked both the depressor and the tachycardiac response evoked by ACh. The current results demonstrate that cardiovascular responses evoked by microinjection of ACh into the PL are mediated by local activation of the M3receptor–NO–guanylate cyclase pathway. © 2015 Wiley Periodicals, Inc.

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Details

Published: Jan 16, 2015
Vol/Issue: 93(5)
Pages: 830-838
License: View

Authors

A

Aline Fassini

Department of Pharmacology School of Medicine of Ribeirão Preto, University of São Paulo Ribeirão Preto São Paulo Brazil

L

Leandro S. Antero

Department of Pharmacology School of Medicine of Ribeirão Preto, University of São Paulo Ribeirão Preto São Paulo Brazil

F

Fernando M.A. Corrêa

Department of Pharmacology School of Medicine of Ribeirão Preto, University of São Paulo Ribeirão Preto São Paulo Brazil

S

Sâmia R. Joca

Department of Physics and Chemistry, Laboratory of Pharmacology School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo Ribeirão Preto São Paulo Brazil

L

Leonardo B.M. Resstel

Department of Pharmacology School of Medicine of Ribeirão Preto, University of São Paulo Ribeirão Preto São Paulo Brazil

Funding

Fundação de Amparo a Pesquisa do Estado de São Paulo Award: 2012/09300-4

Cite This Article

Aline Fassini, Leandro S. Antero, Fernando M.A. Corrêa, et al. (2015). The prelimbic cortex muscarinic M3receptor–nitric oxide–guanylyl cyclase pathway modulates cardiovascular responses in rats. Journal of Neuroscience Research, 93(5), 830-838. https://doi.org/10.1002/jnr.23537

The prelimbic cortex muscarinic M3receptor–nitric oxide–guanylyl cyclase pathway modulates cardiovascular responses in rats

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