Dorsal hippocampus cholinergic and nitrergic neurotransmission modulates the cardiac baroreflex function in rats

Nilson Carlos Ferreira‐Junior; Davi Campos Lagatta; Luciana Bärg Kuntze; Eduardo Akira Fujiwara; Egidi Mayara Silva Firmino; Anna Bárbara Borges‐Assis; Leonardo Barbosa Moraes Resstel; Karla Nívea Sampaio

doi:10.1111/ejn.14599

journal article Dec 05, 2019

Dorsal hippocampus cholinergic and nitrergic neurotransmission modulates the cardiac baroreflex function in rats

Davi Campos Lagatta Luciana Bärg Kuntze Eduardo Akira Fujiwara Egidi Mayara Silva Firmino Anna Bárbara Borges‐Assis Leonardo Barbosa Moraes Resstel Karla Nívea Sampaio

European Journal of Neuroscience Vol. 51 No. 4 pp. 991-1010 · Wiley

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Abstract

AbstractHippocampus is a limbic structure involved in the baroreflex and chemoreflex control that receives extensive cholinergic input from basal forebrain. Hippocampal muscarinic receptors activation by acetylcholine might evoke nitric oxide synthesis, which is an important neuromodulator of cardiovascular responses. Thus, we hypothesize that cholinergic and nitrergic neurotransmission within the DH modulates the baroreflex and chemoreflex function. We have used vasoactive drugs (phenylephrine and sodium nitroprusside), and potassium cyanide infused peripherally to induce, respectively, baroreflex or chemoreflex responses in awake animals. Bilateral injection into the DH of the acetylcholinesterase inhibitor (neostigmine) reduced baroreflex responses. Meanwhile, the non‐selective muscarinic receptor antagonist (atropine) or the M1‐selective muscarinic receptor antagonist increased baroreflex responses (pirenzepine). Furthermore, the neuronal nitric oxide synthase inhibitor (N‐propyl) or the intracellular NO scavenger (carboxy‐PTIO) increased baroreflex responses, as well as the selective inhibitor of NO‐sensitive guanylyl cyclase (ODQ), increased the baroreflex responses. Besides, bilateral administration of an ineffective dose of a neuronal nitric oxide synthase inhibitor abolished the reduction in the baroreflex responses evoked by an acetylcholinesterase inhibitor. On the other hand, we have demonstrated that hippocampal cholinergic neurotransmission did not influence the chemoreflex function. Taken together, our findings suggest that nNOS‐derived nitric oxide in the DH participates in acetylcholine‐evoked baroreflex responses.

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Published: Dec 05, 2019
Vol/Issue: 51(4)
Pages: 991-1010
License: View

Authors

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Nilson Carlos Ferreira‐Junior