Gonadectomy but not biological sex affects burst‐firing in dopamine neurons of the ventral tegmental area and in prefrontal cortical neurons projecting to the ventral tegmentum in adult rats

Mallory N. Locklear; Michalis Michaelos; William F. Collins; Mary F. Kritzer

doi:10.1111/ejn.13380

journal article Sep 19, 2016

Gonadectomy but not biological sex affects burst‐firing in dopamine neurons of the ventral tegmental area and in prefrontal cortical neurons projecting to the ventral tegmentum in adult rats

Mallory N. Locklear Michalis Michaelos William F. Collins Mary F. Kritzer

European Journal of Neuroscience Vol. 45 No. 1 pp. 106-120 · Wiley

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Abstract

AbstractThe mesocortical and mesolimbic dopamine systems regulate cognitive and motivational processes and are strongly implicated in neuropsychiatric disorders in which these processes are disturbed. Sex differences and sex hormone modulation are also known for these dopamine‐sensitive behaviours in health and disease. One relevant mechanism of hormone impact appears to be regulation of cortical and subcortical dopamine levels. This study asked whether this regulation of dopamine tone is a consequence of sex or sex hormone impact on the firing modes of ventral midbrain dopamine neurons. To address this, single unit extracellular recordings made in the ventral tegmental area and substantia nigra were compared among urethane‐anaesthetized adult male, female, gonadectomized male rats. These comparisons showed that gonadectomy had no effect on nigral cells and no effects on pacemaker, bursty, single‐spiking or random modes of dopamine activity in the ventral tegmental area. However, it did significantly and selectively increase burst firing in these cells in a testosterone‐sensitive, estradiol‐insensitive manner. Given the roles of prefrontal cortex (PFC) in modulating midbrain dopamine cell firing, we next asked whether gonadectomy's effects on dopamine cell bursting had correlated effects on the activity of ventral tegmentally projecting prefrontal cortical neurons. We found that gonadectomy indeed significantly and selectively increased burst firing in ventral tegmentally projecting but not neighbouring prefrontal cells. These effects were also androgen‐sensitive. Together, these findings suggest a working model wherein androgen influence over the activity of PFC neurons regulates its top‐down modulation of mesocortical and mesolimbic dopamine systems and related dopamine‐sensitive behaviours.

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Details

Published: Sep 19, 2016
Vol/Issue: 45(1)
Pages: 106-120
License: View

Authors

M

Mallory N. Locklear

Department of Neurobiology and Behavior Stony Brook University Stony Brook NY 11794‐5230 USA

M

Michalis Michaelos

Department of Neurobiology and Behavior Stony Brook University Stony Brook NY 11794‐5230 USA

W

William F. Collins

Department of Neurobiology and Behavior Stony Brook University Stony Brook NY 11794‐5230 USA

M

Mary F. Kritzer

Department of Neurobiology and Behavior Stony Brook University Stony Brook NY 11794‐5230 USA

Funding

National Institutes of Health Award: RO1‐NS41966

National Institute of Neurological Disorders and Stroke

Cite This Article

Mallory N. Locklear, Michalis Michaelos, William F. Collins, et al. (2016). Gonadectomy but not biological sex affects burst‐firing in dopamine neurons of the ventral tegmental area and in prefrontal cortical neurons projecting to the ventral tegmentum in adult rats. European Journal of Neuroscience, 45(1), 106-120. https://doi.org/10.1111/ejn.13380

Gonadectomy but not biological sex affects burst‐firing in dopamine neurons of the ventral tegmental area and in prefrontal cortical neurons projecting to the ventral tegmentum in adult rats

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