Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?

Philipe Souza Corrêa; Aline Souza Pagnussat; Maria Eduarda Parcianello Cabeleira; Giulia Palermo Schifino; Carlos Roberto de Mello Rieder; Neivo da Silva Junior; Fernanda Cechetti

doi:10.1111/ejn.14522

journal article Aug 06, 2019

Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?

Philipe Souza Corrêa

Aline Souza Pagnussat

Maria Eduarda Parcianello Cabeleira

Giulia Palermo Schifino Carlos Roberto de Mello Rieder

Neivo da Silva Junior Fernanda Cechetti

European Journal of Neuroscience Vol. 50 No. 12 pp. 3889-3895 · Wiley

View at Publisher Save 10.1111/ejn.14522

Abstract

AbstractGait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross‐sectional study that included 42 individuals with PD at different motor stages, according to the Hoehn & Yahr scale (H&Y). Motor subsection of the Movement Disorder Society‐Unified Parkinson Disease Rating Scale—part III (MDS‐UPDRS III) was used to evaluate general motor aspects. Gait kinematics was assessed using a three‐dimensional motion capture system. Postural control was assessed by stabilometry using force platforms. Dopamine depletion was verified through 99mTc‐TRODAT‐1 (SPECT‐CT) examination. We included 12, 15 and 15 individuals classified as H&Y I, II and III, respectively. We identified worse values of dopamine transporter uptake, MDS‐UPDRS III, gait parameters (velocity, step length and stride length) and center of pressure displacement as the disease progressed. Our results indicate that higher dopaminergic loss and gait and postural control deficits occur between the H&Y levels II and III.

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References

26

[1]

10.1111/jon2000104200

[2]

10.1016/j.gaitpost.2015.10.014

[3]

10.1186/1471-244x-9-30

[4]

10.1111/ejn.14328

[5]

10.1002/ana.410320721

[6]

Carvalho A. R. D. "Possíveis alterações no mecanismo minimizador de energia da caminhada em decorrência da dor lombar crônica: Revisão de literatura" Brazilian Journal of Rheumatology (2015)

[7]

10.1007/s00221-017-4981-9

[8]

10.1016/0167-9457(91)90046-z

[9]

Revisão sobre posturografia baseada em plataforma de força para avaliação do equilíbrio

Marcos Duarte, Sandra M. S. F. Freitas

Brazilian Journal of Physical Therapy 10.1590/s1413-35552010000300003

[10]

10.1016/j.parkreldis.2016.02.006

[11]

10.3233/jpd-150536

[12]

10.12659/msm.890522

[13]

10.1016/j.parkreldis.2018.05.018

[14]

10.1016/j.neuroimage.2017.02.073

[15]

Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results

Christopher G. Goetz, Barbara C. Tilley, Stephanie R. Shaftman et al.

Movement Disorders 10.1002/mds.22340

[16]

10.2340/16501977-0362

[17]

Parkinsonism

Margaret M. Hoehn, Melvin D. Yahr

Neurology 10.1212/wnl.17.5.427

[18]

Huang W. S. "Evaluation of early‐stage Parkinson's disease with 99mTc‐TRODAT‐1 imaging" Journal of Nuclear Medicine (2001)

[19]

10.1159/000487331

[20]

10.1136/jnnp-2012-302461

[21]

10.1016/j.parkreldis.2019.02.017

[22]

10.1093/brain/124.4.784

[23]

10.1002/mds.21315

[24]

10.4103/1450-1147.144818

[25]

10.1097/rlu.0b013e31829f9119

[26]

10.1016/j.parkreldis.2011.07.014

Metrics

10

Citations

26

References

Details

Published: Aug 06, 2019
Vol/Issue: 50(12)
Pages: 3889-3895
License: View

Authors

P

Philipe Souza Corrêa

Post‐Graduation Program in Rehabilitation Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil

A

Aline Souza Pagnussat

Post‐Graduation Program in Rehabilitation Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil; Post‐Graduation Program in Health Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil

M

Maria Eduarda Parcianello Cabeleira

Post‐Graduation Program in Rehabilitation Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil

G

Giulia Palermo Schifino

Post‐Graduation Program in Rehabilitation Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil

C

Carlos Roberto de Mello Rieder

Post‐Graduation Program in Rehabilitation Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil; Post‐Graduation Program in Health Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil

N

Neivo da Silva Junior

Irmandade Santa Casa de Misericórdia de Porto Alegre Porto Alegre Brazil

F

Fernanda Cechetti

Post‐Graduation Program in Rehabilitation Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Award: Finance Code 001

Cite This Article

Philipe Souza Corrêa, Aline Souza Pagnussat, Maria Eduarda Parcianello Cabeleira, et al. (2019). Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?. European Journal of Neuroscience, 50(12), 3889-3895. https://doi.org/10.1111/ejn.14522

Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?

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