Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system

Chris Q. Doe

doi:10.1242/dev.116.4.855

journal article Dec 01, 1992

Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system

Chris Q. Doe

Development Vol. 116 No. 4 pp. 855-863 · The Company of Biologists

View at Publisher Save 10.1242/dev.116.4.855

Abstract

ABSTRACT
The first step in generating cellular diversity in the Drosophila central nervous system is the formation of a segmentally reiterated array of neural precursor cells, called neuroblasts. Subsequently, each neuroblast goes through an invariant cell lineage to generate neurons and/or glia. Using molecular lineage markers, I show that (1) each neuroblast forms at a stereotyped time and position; (2) the neuroblast pattern is indistinguishable between thoracic and abdominal segments; (3) the development of individual neuroblasts can be followed throughout early neurogenesis; (4) gene expression in a neuroblast can be reproducibly modulated during its cell lineage; (5) identified ganglion mother cells form at stereotyped times and positions; and (6) the cell lineage of four well-characterized neurons can be traced back to two identified neuroblasts. These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages.

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Details

Published: Dec 01, 1992
Vol/Issue: 116(4)
Pages: 855-863
License: View

Authors

C

Chris Q. Doe

University of Illinois Department of Cell and Structural Biology , , Urbana, Illinois 61801, USA

Cite This Article

Chris Q. Doe (1992). Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system. Development, 116(4), 855-863. https://doi.org/10.1242/dev.116.4.855

Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system

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