Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

Xi-Feng Zhang; Zhi-Guo Liu; Wei Shen; Sangiliyandi Gurunathan

doi:10.3390/ijms17091534

journal article Open Access Sep 13, 2016

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

Xi-Feng Zhang Zhi-Guo Liu

Wei Shen

Sangiliyandi Gurunathan

International Journal of Molecular Sciences Vol. 17 No. 9 pp. 1534 · MDPI AG

View at Publisher Save 10.3390/ijms17091534

Abstract

Recent advances in nanoscience and nanotechnology radically changed the way we diagnose, treat, and prevent various diseases in all aspects of human life. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. AgNPs play an important role in nanoscience and nanotechnology, particularly in nanomedicine. Although several noble metals have been used for various purposes, AgNPs have been focused on potential applications in cancer diagnosis and therapy. In this review, we discuss the synthesis of AgNPs using physical, chemical, and biological methods. We also discuss the properties of AgNPs and methods for their characterization. More importantly, we extensively discuss the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral, anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti-cancer activity of AgNPs. In addition, we discuss therapeutic approaches and challenges for cancer therapy using AgNPs. Finally, we conclude by discussing the future perspective of AgNPs.

Topics

No keywords indexed for this article. Browse by subject →

References

282

[1]

Gurunathan "Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: Targeting p53 for anticancer therapy" Int. J. Nanomed. (2015) 10.2147/ijn.s83953

[2]

Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli

Wen-Ru Li, Xiao-Bao Xie, Qing-Shan Shi et al.

Applied Microbiology and Biotechnology 2010 10.1007/s00253-009-2159-5

[3]

Mukherjee "Fungus-mediated synthesis of silver nanoparticles and their immobilization in the mycelial matrix: A novel biological approach to nanoparticle synthesis" Nano Lett. (2001) 10.1021/nl0155274

[4]

Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal

Svitlana Chernousova, Matthias Epple

Angewandte Chemie International Edition 2013 10.1002/anie.201205923

[5]

Li "In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window" Biomaterials (2014) 10.1016/j.biomaterials.2013.10.010

[6]

Sondi "Silver nanoparticles as antimicrobial agent: A case study on E. coli as a model for Gram-negative bacteria" J. Colloid Interface Sci. (2004) 10.1016/j.jcis.2004.02.012

[7]

Li "Band gap variation of size- and shape-controlled colloidal CdSe quantum rods" Nano Lett. (2001) 10.1021/nl015559r

[8]

Sharma "Silver nanoparticles: Green synthesis and their antimicrobial activities" Adv. Colloid Interface (2009) 10.1016/j.cis.2008.09.002

[9]

Gurunathan "Biosynthesis, purification and characterization of silver nanoparticles using Escherichia coli" Colloids Surf. B Biointerfaces (2009) 10.1016/j.colsurfb.2009.07.048

[10]

Lin "Techniques for physicochemical characterization of nanomaterials" Biotechnol. Adv. (2014) 10.1016/j.biotechadv.2013.11.006

[11]

Pleus, R. (2012). Nanotechnologies-Guidance on Physicochemical Characterization of Engineered Nanoscale Materials for Toxicologic Assessment, ISO.

[12]

Murdock "Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique" Toxicol. Sci. (2008) 10.1093/toxsci/kfm240

[13]

Gurunathan "Reduction of graphene oxide by resveratrol: A novel and simple biological method for the synthesis of an effective anticancer nanotherapeutic molecule" Int. J. Nanomed. (2015) 10.2147/ijn.s79879

[14]

Sapsford "Analyzing nanomaterial bioconjugates: A review of current and emerging purification and characterization techniques" Anal. Chem. (2011) 10.1021/ac200853a

[15]

Carlson "Unique cellular interaction of silver nanoparticles: Size-dependent generation of reactive oxygen species" J. Phys. Chem. B (2008) 10.1021/jp712087m

[16]

Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases

Dong Hyun Jo, Jin Hyoung Kim, Tae Geol Lee et al.

Nanomedicine: Nanotechnology, Biology and Medicine 2015 10.1016/j.nano.2015.04.015

[17]

Staquicini "Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma" J. Clin. Investig. (2011) 10.1172/jci44798

[18]

Duan "Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking" Small (2013) 10.1002/smll.201201390

[19]

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

Alexandre Albanese, Peter S. Tang, Wan-Mui Chan

Annual Review of Biomedical Engineering 2012 10.1146/annurev-bioeng-071811-150124

[20]

Prucek "Antifungal activity of silver nanoparticles against Candida spp." Biomaterials (2009) 10.1016/j.biomaterials.2009.07.065

[21]

Zodrow "Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal" Water Res. (2009) 10.1016/j.watres.2008.11.014

[22]

Wong "Further evidence of the anti-inflammatory effects of silver nanoparticles" ChemMedChem (2009) 10.1002/cmdc.200900049

[23]

Gurunathan "Antiangiogenic properties of silver nanoparticles" Biomaterials (2009) 10.1016/j.biomaterials.2009.08.008

[24]

Sriram "Antitumor activity of silver nanoparticles in Dalton’s lymphoma ascites tumor model" Int. J. Nanomed. (2010)

[25]

American Cancer Society (2015). Cancer Facts & Figures 2015, American Cancer Society.

[26]

Gurav "Generation of nanometer-size fullerene particles via vapor condensation" Chem. Phys. Lett. (1994) 10.1016/0009-2614(93)e1491-x

[27]

Kruis "Sintering and evaporation characteristics of gas-phase synthesis of size-selected PbS nanoparticles" Mater. Sci. Eng. B (2000) 10.1016/s0921-5107(99)00298-6

[28]

Magnusson "Size-selected gold nanoparticles by aerosol technology" Nanostruct. Mater. (1999) 10.1016/s0965-9773(99)00063-x

[29]

"New approaches to in situ characterization of ultrafine agglomerates" J. Aerosol Sci. (1988) 10.1016/0021-8502(88)90207-8

[30]

Tien "Novel technique for preparing a nano-silver water suspension by the arc-discharge method" Rev. Adv. Mater. Sci. (2008)

[31]

Pluym "Solid silver particle production by spray pyrolysis" J. Aerosol Sci. (1993) 10.1016/0021-8502(93)90010-7

[32]

Elsupikhe "Green sonochemical synthesis of silver nanoparticles at varying concentrations of κ-carrageenan" Nanoscale Res. Lett. (2015) 10.1186/s11671-015-0916-1

[33]

Shameli "Synthesis of silver/montmorillonite nanocomposites using γ-irradiation" Int. J. Nanomed. (2010) 10.2147/ijn.s15033

[34]

Shameli "Green synthesis of silver/montmorillonite/chitosan bionanocomposites using the UV irradiation method and evaluation of antibacterial activity" Int. J. Nanomed. (2010) 10.2147/ijn.s13632

[35]

Tsuji "Microwave-assisted synthesis of metallic nanostructures in solution" Chem. Eur. J. (2005) 10.1002/chem.200400417

[36]

Eftaiha "Synthesis and applications of silver nanoparticles" Arab. J. Chem. (2010) 10.1016/j.arabjc.2010.04.008

[37]

Tao "Polyhedral silver nanocrystals with distinct scattering signatures" Angew. Chem. Int. Ed. (2006) 10.1002/anie.200601277

[38]

Wiley "Shape-controlled synthesis of metal nanostructures: The case of silver" Chemistry (2005) 10.1002/chem.200400927

[39]

Deepak "Synthesis of gold and silver nanoparticles using purified URAK" Colloid Surface B (2011) 10.1016/j.colsurfb.2011.04.019

[40]

Amulyavichus "Study of chemical composition of nanostructural materials prepared by laser cutting of metals" Fiz. Met. Metalloved. (1998)

[41]

Mallick "Polymer stabilized silver nanoparticles: A photochemical synthesis route" J. Mater. Sci. (2004) 10.1023/b:jmsc.0000034138.80116.50

[42]

Malik "A simple route to the synthesis of core/shell nanoparticles of chalcogenides" Chem. Mater. (2002) 10.1021/cm011154w

[43]

Sergeev "Cryochemical synthesis and properties of silver nanoparticle dispersions stabilised by poly(2-dimethylaminoethyl methacrylate)" Mendeleev Commun. (1999) 10.1070/mc1999v009n04abeh001080

[44]

Kohno "Formation and size control of silver nanoparticles by laser ablation in aqueous solution" J. Phys. Chem. B (2000) 10.1021/jp001336y

[45]

Hulteen "Nanosphere lithography: Size-tunable silver nanoparticle and surface cluster arrays" J. Phys. Chem. B (1999) 10.1021/jp9904771

[46]

Zhu "Preparation of silver nanorods by electrochemical methods" Mater. Lett. (2001) 10.1016/s0167-577x(00)00349-9

[47]

Abid "Preparation of silver nanoparticles in solution from a silver salt by laser irradiation" Chem. Commun. (2002) 10.1039/b200272h

[48]

Talebi "Sonochemical synthesis of silver nanoparticles in Y-zeolite substrate" J. Mater. Sci. (2010) 10.1007/s10853-010-4349-z

[49]

Ramezani "Silver and silver oxide nanoparticles: Synthesis and characterization by thermal decomposition" Mater. Lett. (2014) 10.1016/j.matlet.2014.05.133

[50]

Zhang "A systematic study of the synthesis of silver nanoplates: Is citrate a “Magic” Reagent?" J. Am. Chem. Soc. (2011) 10.1021/ja2080345

Showing 50 of 282 references

Cited By

2,704

Eco-inspired synthesis of silver nanoparticles from Prunus avium stems: Mechanistic insights into multifunctional biomedical activities

Hamideh Dehghan, Pouria Mohammadparast-Tabas · 2026

Materials Today Communications

Antibacterial and antiviral activities of SiO2-Ag and ZrO2-Ag nanocomposite coatings deposited on polymeric air filters

Domiziana Porporato, Angelica Luceri · 2026

Ceramics International

Unravelling the effects of silver nanoparticles on textiles: a comprehensive toxicological and quantitative analysis

Lisia M. G. dos Santos, Renata J. Medeiros · 2025

Health Nanotechnology

Green Synthesis and Characterization of Limonium sinuatum Silver Nanoparticles (AgNPs) for Antioxidant and Antimicrobial Applications

Oromia Girma Kebede, Nur Pasaoglulari Aydinlik · 2024

Analytical Letters

Biogenic synthesis of silver nanoparticle from flower extract of Wedelia chinensis and their antibacterial and antioxidant activity

Brajesh Chandra Pandey, Ashish Gupta · 2024

Nano Express

Antimicrobial silver nanoparticles for water disinfection: a short review on recent advances

Tanmoy Dutta, Ananya Barman · 2023

Nanotechnology for Environmental En...

Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS‐2B Cell Lines

Musthahimah Muhamad, Nurhidayah Ab.Rahim · 2022

Bioinorganic Chemistry and Applicat...

Green Route Synthesis and Characterization Techniques of Silver Nanoparticles and Their Biological Adeptness

Nitin Kumar Sharma, Jyotsna Vishwakarma · 2022

ACS Omega

Antidiabetic and Hypolipidemic Potential of Green AgNPs against Diabetic Mice

Salim Ullah, Syed Wadud Ali Shah · 2021

ACS Applied Bio Materials

Synthesis of Chitosan-Coated Silver Nanoparticle Bioconjugates and Their Antimicrobial Activity against Multidrug-Resistant Bacteria

Surbhi Shinde, Veronica Folliero · 2021

Applied Sciences

Characterization of bio‐fabricated silver nanoparticles for distinct anti‐fungal activity against sugarcane phytopathogens

Amna, Tariq Mahmood · 2021

Microscopy Research and Technique

Green Synthesis of Silver Nanoparticles Using Pomegranate and Orange Peel Extracts and Their Antifungal Activity against Alternaria solani, the Causal Agent of Early Blight Disease of Tomato

Yasser S. Mostafa, Saad A. Alamri · 2021

Plants

Small RNAs as a New Platform for Tuning the Biosynthesis of Silver Nanoparticles for Enhanced Material and Functional Properties

Angela Chen, Julia Hernandez-Vargas · 2021

ACS Applied Materials & Interfa...

Green synthesis of silver nanostructures with amino acid-modified Pluronic F127 for antibacterial applications

Douglas C. Santos, João M.R. Goes · 2020

Applied Surface Science

Extracellular biosynthesis of silver nanoparticles from Penicillium italicum and its antioxidant, antimicrobial and cytotoxicity activities

Zainab K. Taha, Sumaiya N. Hawar · 2019

Biotechnology Letters

Metrics

2,704

Citations

282

References

Details

Published: Sep 13, 2016
Vol/Issue: 17(9)
Pages: 1534
License: View

Authors

X

Xi-Feng Zhang

College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China

Z

Zhi-Guo Liu

College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China

W

Wei Shen

Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China

S

Sangiliyandi Gurunathan

Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 143-701, Korea

Cite This Article

Xi-Feng Zhang, Zhi-Guo Liu, Wei Shen, et al. (2016). Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches. International Journal of Molecular Sciences, 17(9), 1534. https://doi.org/10.3390/ijms17091534

Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

You May Also Like