The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley; Devon Jeltema; Yanhui Duan; Yuan He

doi:10.3390/ijms20133328

journal article Open Access Jul 06, 2019

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley Devon Jeltema Yanhui Duan Yuan He

International Journal of Molecular Sciences Vol. 20 No. 13 pp. 3328 · MDPI AG

View at Publisher Save 10.3390/ijms20133328

Abstract

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. However, the aberrant activation of the NLRP3 inflammasome has been linked with several inflammatory disorders, which include cryopyrin-associated periodic syndromes, Alzheimer’s disease, diabetes, and atherosclerosis. The NLRP3 inflammasome is activated by diverse stimuli, and multiple molecular and cellular events, including ionic flux, mitochondrial dysfunction, and the production of reactive oxygen species, and lysosomal damage have been shown to trigger its activation. How NLRP3 responds to those signaling events and initiates the assembly of the NLRP3 inflammasome is not fully understood. In this review, we summarize our current understanding of the mechanisms of NLRP3 inflammasome activation by multiple signaling events, and its regulation by post-translational modifications and interacting partners of NLRP3.

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Details

Published: Jul 06, 2019
Vol/Issue: 20(13)
Pages: 3328
License: View

Authors

N

Nathan Kelley

Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA

D

Devon Jeltema

Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA

Y

Yanhui Duan

Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA

Y

Yuan He

Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA

Cite This Article

Nathan Kelley, Devon Jeltema, Yanhui Duan, et al. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. International Journal of Molecular Sciences, 20(13), 3328. https://doi.org/10.3390/ijms20133328

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

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