Anti-Inflammatory Components from the Root of  Solanum erianthum

Yu-Chang Chen; Hong-Zin Lee; Hsin-Chun Chen; Chi-Luan Wen; Yueh-Hsiung Kuo; Guei-Jane Wang

doi:10.3390/ijms140612581

journal article Open Access Jun 14, 2013

Anti-Inflammatory Components from the Root of Solanum erianthum

Yu-Chang Chen Hong-Zin Lee Hsin-Chun Chen Chi-Luan Wen Yueh-Hsiung Kuo

Guei-Jane Wang

International Journal of Molecular Sciences Vol. 14 No. 6 pp. 12581-12592 · MDPI AG

View at Publisher Save 10.3390/ijms140612581

Abstract

Two new norsesquiterpenoids, solanerianones A and B (1–2), together with nine known compounds, including four sesquiterpenoids, (−)-solavetivone (3), (+)-anhydro-β-rotunol (4), solafuranone (5), lycifuranone A (6); one alkaloid, N-trans-feruloyltyramine (7); one fatty acid, palmitic acid (8); one phenylalkanoid, acetovanillone (9), and two steroids, β-sitosterol (10) and stigmasterol (11) were isolated from the n-hexane-soluble part of the roots of Solanum erianthum. Their structures were elucidated on the basis of physical and spectroscopic data analyses. The anti-inflammatory activity of these isolates was monitored by nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells. The cytotoxicity towards human lung squamous carcinoma (CH27), human hepatocellular carcinoma (Hep 3B), human oral squamous carcinoma (HSC-3) and human melanoma (M21) cell lines was also screened by using an MTT assay. Of the compounds tested, 3 exhibited the strongest NO inhibition with the average maximum inhibition (Emax) at 100 μM and median inhibitory concentration (IC50) values of 98.23% ± 0.08% and 65.54 ± 0.18 μM, respectively. None of compounds (1–9) was found to possess cytotoxic activity against human cancer cell lines at concentrations up to 30 μM.

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Details

Published: Jun 14, 2013
Vol/Issue: 14(6)
Pages: 12581-12592
License: View

Authors

Y

Yu-Chang Chen

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan

H

Hong-Zin Lee

School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan

H

Hsin-Chun Chen

Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan

C

Chi-Luan Wen

Taiwan Seed Improvement and Propagation Station, Council of Agriculture, Taichung 426, Taiwan

Y

Yueh-Hsiung Kuo

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan; Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan

G

Guei-Jane Wang

Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan

Cite This Article

Yu-Chang Chen, Hong-Zin Lee, Hsin-Chun Chen, et al. (2013). Anti-Inflammatory Components from the Root of Solanum erianthum. International Journal of Molecular Sciences, 14(6), 12581-12592. https://doi.org/10.3390/ijms140612581

Anti-Inflammatory Components from the Root of Solanum erianthum

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