DNA Damage, Mutagenesis and Cancer

Ashis Basu

doi:10.3390/ijms19040970

journal article Open Access Mar 23, 2018

DNA Damage, Mutagenesis and Cancer

Ashis Basu

International Journal of Molecular Sciences Vol. 19 No. 4 pp. 970 · MDPI AG

View at Publisher Save 10.3390/ijms19040970

Abstract

A large number of chemicals and several physical agents, such as UV light and γ-radiation, have been associated with the etiology of human cancer. Generation of DNA damage (also known as DNA adducts or lesions) induced by these agents is an important first step in the process of carcinogenesis. Evolutionary processes gave rise to DNA repair tools that are efficient in repairing damaged DNA; yet replication of damaged DNA may take place prior to repair, particularly when they are induced at a high frequency. Damaged DNA replication may lead to gene mutations, which in turn may give rise to altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a gene that controls the cell cycle can generate a clonal cell population with a distinct advantage in proliferation. Many such events, broadly divided into the stages of initiation, promotion, and progression, which may occur over a long period of time and transpire in the context of chronic exposure to carcinogens, can lead to the induction of human cancer. This is exemplified in the long-term use of tobacco being responsible for an increased risk of lung cancer. This mini-review attempts to summarize this wide area that centers on DNA damage as it relates to the development of human cancer.

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References

107

[1]

Brown "Percivall Pott (1714–1788) and chimney sweepers’ cancer of the scrotum" Br. J. Ind. Med. (1957)

[2]

Yamagiwa "Experimental Study of the Pathogenesis of Carcinoma" Cancer Res. (1918)

[3]

Yamagiwa "Experimental study of the pathogenesis of carcinoma" CA Cancer J. Clin. (1977) 10.3322/canjclin.27.3.174

[4]

Tsutsui "Uber das kustlich erzeugte cancroid bei der maus" Gann (1918)

[5]

Cook "The production of cancer by pure hydrocarbons" R. Soc. Proc. (1932)

[6]

Cook, J.W., Hewett, C.L., and Hieger, I. (1933). The isolation of a cancer-producing hydrocarbon from coal tar. Parts I, II, and III. J. Chem. Soc., 395–405. 10.1039/jr9330000395

[7]

Stern "Notification and risk assessment for bladder cancer of a cohort exposed to aromatic amines. III. Mortality among workers exposed to aromatic amines in the last beta-naphthylamine manufacturing facility in the United States" J. Occup. Med. (1985)

[8]

Michaels "When Science Isn’t Enough: Wilhelm Hueper, Robert A. M. Case, and the Limits of Scientific Evidence in Preventing Occupational Bladder Cancer" Int. J. Occup. Environ. Health (1995) 10.1179/oeh.1995.1.3.278

[9]

Clayson "Specific aromatic amines as occupational bladder carcinogens" Natl. Cancer Inst. Monogr. (1981)

[10]

Purohit "Mutagenicity of nitroaromatic compounds" Chem. Res. Toxicol. (2000) 10.1021/tx000002x

[11]

Nicholson "The carcinogenicity of chrysotile asbestos—A review" Ind. Health (2001) 10.2486/indhealth.39.57

[12]

Hayes "The carcinogenicity of metals in humans" Cancer Causes Control (1997) 10.1023/a:1018457305212

[13]

Brady "Angiosarcoma of the liver: An epidemiologic survey" J. Natl. Cancer Inst. (1977) 10.1093/jnci/59.5.1383

[14]

Wogan "Aflatoxin as a human carcinogen" Hepatology (1999) 10.1002/hep.510300231

[15]

Taxell "Diesel Engine Exhaust: Basis for Occupational Exposure Limit Value" Toxicol. Sci. (2017) 10.1093/toxsci/kfx110

[16]

Hecht "Tobacco smoke carcinogens and lung cancer" J. Natl. Cancer Inst. (1999) 10.1093/jnci/91.14.1194

[17]

Soehnge "Mechanisms of induction of skin cancer by UV radiation" Front. Biosci. (1997) 10.2741/a211

[18]

Robock "Local nuclear war, global suffering" Sci. Am. (2010) 10.1038/scientificamerican0110-74

[19]

IARC (2000). Ionizing Radiation: Part 1: X- and Gamma (y)-Radiation, and Neutrons (IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans) (Pt. 1), IARC. [1st ed.].

[20]

Boyland "Metabolism of polycyclic compounds. 6. Conversion of phenanthrene into dihydroxydihydrophenanthrenes" Biochem. J. (1950) 10.1042/bj0470064

[21]

Avery "Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III" J. Exp. Med. (1944) 10.1084/jem.79.2.137

[22]

THE STRUCTURE OF DNA

J. D. WATSON, F. H. C. Crick

Cold Spring Harbor Symposia on Quantitative Biolog... 1953 10.1101/sqb.1953.018.01.020

[23]

Miller "Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address" Cancer Res. (1978)

[24]

Wogan "Environmental and chemical carcinogenesis" Semin. Cancer Biol. (2004) 10.1016/j.semcancer.2004.06.010

[25]

Pullman "Electronic structure and carcinogenic activity of aromatic molecules; new developments" Adv. Cancer Res. (1955) 10.1016/s0065-230x(08)60919-7

[26]

Harvey "Historical Overview of Chemical Carcinogenesis" Curr. Cancer Res. (2011)

[27]

Singer, B., and Grunberger, D. (1983). Molecular Biology of Mutagens and Carcinogens, Plenum Press. 10.1007/978-1-4613-3772-0

[28]

Varghese "Ultraviolet irradiation of DNA in vitro and in vivo produces a 3d thymine-derived product" Science (1967) 10.1126/science.156.3777.955

[29]

Wang "Cytosine-thymine addition product from DNA irradiated with ultraviolet light" Biochem. Biophys. Res. Commun. (1967) 10.1016/0006-291x(67)90519-0

[30]

Wang "Concerning the mechanism of formation of UV-induced thymine photoproducts in DNA" Proc. Natl. Acad. Sci. USA (1967) 10.1073/pnas.57.2.465

[31]

Varghese "Cis-syn thymine homodimer from ultra-violet irradiated calf thymus DNA" Nature (1967) 10.1038/213909a0

[32]

Berenblum "The persistence of latent tumor cells induced in the mouse’s skin by a single application of 9,10-dimethyl-1,2-benzanthracene" Br. J. Cancer (1949) 10.1038/bjc.1949.42

[33]

Hecker "Phorbol esters from croton oil. Chemical nature and biological activities" Naturwissenschaften (1967) 10.1007/bf00620887

[34]

Argyris "Promotion of carcinomas by repeated abrasion in initiated skin of mice" Cancer Res. (1981)

[35]

Reiners "Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion" Carcinogenesis (1984) 10.1093/carcin/5.3.301

[36]

Naito "Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents" Carcinogenesis (1987) 10.1093/carcin/8.12.1807

[37]

Walborg "Short-term biomarkers of tumor promotion in mouse skin treated with petroleum middle distillates" Toxicol. Sci. (1998)

[38]

McCann "Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals" Proc. Natl. Acad. Sci. USA (1975) 10.1073/pnas.72.12.5135

[39]

Cupples "A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions" Proc. Natl. Acad. Sci. USA (1989) 10.1073/pnas.86.14.5345

[40]

Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system

D. Clive, K.O. Johnson, J.F.S. Spector et al.

Mutation Research 1979 10.1016/0027-5107(79)90195-7

[41]

Kraemer "Use of supF, an Escherichia coli tyrosine suppressor tRNA gene, as a mutagenic target in shuttle-vector plasmids" Mutat. Res. (1989) 10.1016/0165-1110(89)90011-0

[42]

Ohkawa "A rapid, simple screening method for skin-tumor promoters using mouse peritoneal macrophages in vitro" Cancer Lett. (1984) 10.1016/0304-3835(84)90003-x

[43]

Vogelstein "Genetic alterations during colorectal-tumor development" N. Engl. J. Med. (1988) 10.1056/nejm198809013190901

[44]

Kinzler "Lessons from hereditary colorectal cancer" Cell (1996) 10.1016/s0092-8674(00)81333-1

[45]

"Why cancer and inflammation?" Yale J. Biol. Med. (2006)

[46]

Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 Years

Christopher J. Kemp

Cold Spring Harbor Protocols 10.1101/pdb.top069906

[47]

Fujiki "Indole alkaloids: Dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters" Proc. Natl. Acad. Sci. USA (1981) 10.1073/pnas.78.6.3872

[48]

Fujiki "New classes of tumor promoters: Teleocidin, aplysiatoxin, and palytoxin" Adv Cancer Res (1987) 10.1016/s0065-230x(08)60799-x

[49]

DiGiovanni "Multistage carcinogenesis in mouse skin" Pharmacol. Ther. (1992) 10.1016/0163-7258(92)90051-z

[50]

Castagna "Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters" J. Biol. Chem. (1982) 10.1016/s0021-9258(18)34459-4

Showing 50 of 107 references

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