Pathophysiology of Atherosclerosis

Shifa Jebari-Benslaiman; Unai Galicia-García; Asier Larrea-Sebal; Javier Rekondo Olaetxea; Iraide Alloza; Koen Vandenbroeck; Asier Benito-Vicente; César Martín

doi:10.3390/ijms23063346

journal article Open Access Mar 20, 2022

Pathophysiology of Atherosclerosis

Shifa Jebari-Benslaiman Unai Galicia-García Asier Larrea-Sebal Javier Rekondo Olaetxea Iraide Alloza Koen Vandenbroeck Asier Benito-Vicente César Martín

International Journal of Molecular Sciences Vol. 23 No. 6 pp. 3346 · MDPI AG

View at Publisher Save 10.3390/ijms23063346

Abstract

Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The resultant atheroma plaque, along with these processes, results in cardiovascular complications. This review focuses on the different stages of atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, the post-transcriptional regulation and modulation of atheroma plaque by microRNAs and lncRNAs, the role of microbiota, and the importance of sex as a crucial risk factor in atherosclerosis are covered here in order to provide a global view of the disease.

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Details

Published: Mar 20, 2022
Vol/Issue: 23(6)
Pages: 3346
License: View

Authors

S

Shifa Jebari-Benslaiman

Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, 48940 Leioa, Bizkaia, Spain; Biofisika Institute (UPV/EHU, CSIC), Barrio Sarriena s/n., 48940 Leioa, Bizkaia, Spain

U

Unai Galicia-García

Biofisika Institute (UPV/EHU, CSIC), Barrio Sarriena s/n., 48940 Leioa, Bizkaia, Spain; Fundación Biofisika Bizkaia, Barrio Sarriena s/n., 48940 Leioa, Bizkaia, Spain

A

Asier Larrea-Sebal

Biofisika Institute (UPV/EHU, CSIC), Barrio Sarriena s/n., 48940 Leioa, Bizkaia, Spain; Fundación Biofisika Bizkaia, Barrio Sarriena s/n., 48940 Leioa, Bizkaia, Spain

J

Javier Rekondo Olaetxea

Cardiology Department, Basurto University Hospital, 48013 Bilbao, Bizkaia, Spain

I

Iraide Alloza

Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, 48940 Leioa, Bizkaia, Spain; Inflammation & Biomarkers Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Bizkaia, Spain

K

Koen Vandenbroeck

Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, 48940 Leioa, Bizkaia, Spain; Inflammation & Biomarkers Group, Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Bizkaia, Spain; Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Bizkaia, Spain

A

Asier Benito-Vicente

Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, 48940 Leioa, Bizkaia, Spain; Biofisika Institute (UPV/EHU, CSIC), Barrio Sarriena s/n., 48940 Leioa, Bizkaia, Spain

C

César Martín

Department of Biochemistry and Molecular Biology, Universidad del País Vasco UPV/EHU, 48940 Leioa, Bizkaia, Spain; Biofisika Institute (UPV/EHU, CSIC), Barrio Sarriena s/n., 48940 Leioa, Bizkaia, Spain

Cite This Article

Shifa Jebari-Benslaiman, Unai Galicia-García, Asier Larrea-Sebal, et al. (2022). Pathophysiology of Atherosclerosis. International Journal of Molecular Sciences, 23(6), 3346. https://doi.org/10.3390/ijms23063346

Pathophysiology of Atherosclerosis

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