Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease

Min Qiu; Jimei Chen; Xiaohong Li; Jian Zhuang

doi:10.3390/ijms232012197

journal article Open Access Oct 13, 2022

Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease

Min Qiu

Jimei Chen Xiaohong Li

Jian Zhuang

International Journal of Molecular Sciences Vol. 23 No. 20 pp. 12197 · MDPI AG

View at Publisher Save 10.3390/ijms232012197

Abstract

Cardiovascular diseases (CVDs) present a major social problem worldwide due to their high incidence and mortality rate. Many pathophysiological mechanisms are involved in CVDs, and oxidative stress plays a vital mediating role in most of these mechanisms. The ubiquitin–proteasome system (UPS) is the main machinery responsible for degrading cytosolic proteins in the repair system, which interacts with the mechanisms regulating endoplasmic reticulum homeostasis. Recent evidence also points to the role of UPS dysfunction in the development of CVDs. The UPS has been associated with oxidative stress and regulates reduction–oxidation homeostasis. However, the mechanisms underlying UPS-mediated oxidative stress’s contribution to CVDs are unclear, especially the role of these interactions at different disease stages. This review highlights the recent research progress on the roles of the UPS and oxidative stress, individually and in combination, in CVDs, focusing on the pathophysiology of key CVDs, including atherosclerosis, ischemia–reperfusion injury, cardiomyopathy, and heart failure. This synthesis provides new insight for continued research on the UPS–oxidative stress interaction, in turn suggesting novel targets for the treatment and prevention of CVDs.

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Details

Published: Oct 13, 2022
Vol/Issue: 23(20)
Pages: 12197
License: View

Authors

M

Min Qiu

Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China; Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

J

Jimei Chen

Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China; Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

X

Xiaohong Li

Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

J

Jian Zhuang

Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China; Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

Funding

National Natural Science Foundation of China Award: 82170259

Science and Technology Planning Project of Guangdong Province Award: 82170259

Science and Technology Program of Guangzhou, China Award: 82170259

Cite This Article

Min Qiu, Jimei Chen, Xiaohong Li, et al. (2022). Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease. International Journal of Molecular Sciences, 23(20), 12197. https://doi.org/10.3390/ijms232012197

Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease

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